In Reply.—Dr Vlassov is correct when
he states that a MEDLINE search using headings such as lungs/respiration and space recovers a number
of Russian articles. However, almost none of these are relevant to our measurements
in Spacelab, which were made under carefully controlled conditions with extensive
preflight and postflight controls. These articles contain a few published
measurements of respiratory rate, vital capacity, and total ventilation in
microgravity, but all data show great variability, probably because the measurement
conditions were much more difficult to control than in Spacelab, which was
specifically designed for scientific studies. The Russian articles dealing
with immersion can be discounted because this is not a useful model of the
lung in microgravity; immersion does not reduce the effects of gravity on
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