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Letters |

Adult Purpura Fulminans and Digital Necrosis Associated With Sepsis and the Factor V Mutation

Roger T. Jackson, MD; Rolland E. Luplow III, MD
JAMA. 1998;280(21):1829-1830. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-21-jbk1202.
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To the Editor.—Two adults with purpura fulminans related to sepsis were found to be heterozygous for the Factor V Leiden mutation. Each patient survived disseminated intravascular coagulation (DIC), shock, and digital necrosis, but eventually required digit amputations. We believe the underlying congenital hypercoaguable risk factor contributed to the severity of the clinical course.

Carpenter  CTKaiser  AB Purpura fulminans in pneumococcal sepsis: case report and review. Scand J Infect Dis. 1997;29479- 483
Link to Article[[XSLOpenURL/10.3109/00365549709011858]]
Pipe  SWSchmaier  AHNichols  WC  et al.  Neonatal purpura fulminans in association with factor V R506Q mutation. J Pediatr. 1996;128706- 709
Link to Article[[XSLOpenURL/10.1016/S0022-3476(96)80142-9]]
Sackesen  CSecmeer  GGurgey  A  et al.  Homozygous factor V Leiden mutation in a child with meningococcal purpura fulminans. Pediatr Infect Dis J. 1998;1787
Inbal  AKenet  GZivelin  A  et al.  Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. Thromb Haemost. 1997;771086- 1089
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