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November 11, 1998, Vol 280, No. 18 >

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Books, Journals, New Media | November 11, 1998

Ethics

Heiner K. Berthold, MD, PhD; Thomas Sudhop, MD; Klaus von Bergmann, MD
JAMA. 1998;280(18):1568. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111.
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In Reply.— We agree with Dr Lawson that garlic oil is not the same as garlic and that there are differences between various garlic preparations. Lawson criticizes our study for our choice of a steam-distilled garlic oil bound to a beta cyclodextrin matrix, suggesting that use of a water-soluble preparation would have shown lipid-lowering effects. We believe there is little evidence that powder preparations have lipid-lowering effects, even if Lawson attributes to them a significant efficacy on the basis of 17 of 20 studies cited in his recent review.1 Almost all of these studies were not as rigorously designed as 2 studies that used the popular allicin-standardized powder preparation (Kwai) and that showed no effect on blood lipids.2- 3 We believe the negative result of our study is hardly attributable to the use of an oily preparation.

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