To the Editor.—The conclusion of the article by Dr Rimm and colleagues1 and the Editorial by Dr McCully2 that intake of folate and vitamin B6above the current dietary content may be important in the primary prevention of coronary heart disease (CHD) in women is not warranted because the data do not prove that the association established is a causal one. For such proof, controlled trials with homocysteine-lowering therapy are required.
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