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David Callanan, MD; Barbara A. Blodi, MD; Daniel F. Martin, MD
JAMA. 1998;279(21):1702. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-21-jbk0603.
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To the Editor.—Oral nicotinic acid (niacin) lowers serum cholesterol levels when taken in high doses.1 Although nicotinic acid has not achieved widespread use, its low cost makes it attractive in today's cost-conscious medical environment and its use may be increasing. In this report, we describe 3 patients who developed visual loss while taking nicotinic acid for hypercholesterolemia.

Parsons Jr  WBFlinn  JH Reduction in elevated blood cholesterol levels by large doses of nicotinic acid: preliminary report. JAMA. 1957;165234- 238
Link to Article[[XSLOpenURL/10.1001/jama.1957.02980210030009]]
Gass  JDM Nicotinic acid maculopathy. Am J Ophthalmol. 1973;76500- 510
Millay  RHKlein  MLIllingworth  DR Niacin maculopathy. Ophthalmology. 1988;95930- 936
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A, petaloid appearance of cystoid macular edema; B, Fluorescein angiogram showing no leakage of dye in macula; C, Normal macula with resolution of cystoid macular edema.

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