Letters |

Zyban: Two Products, Two Uses—Too Confusing?

Michael R. Bubb, MD
JAMA. 1998;279(21):1701-1702. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-21-jbk0603.
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To the Editor.—Physicians should be alerted to the unfortunate choice of names for the smoking cessation drug, Zyban or bupropion hydrochloride. Zyban (Grace-Sierra Co, Malpitas, Calif) is also the trade name for thiophanate with mancozeb, one of the few fungicides still approved and widely used in many areas of the United States for residential and nursery applications (Figure 1). An active metabolite of Zyban (for horticulture use) is a benzimidazole that binds β-tubulin and inhibits microtubule function. The benzimidazoles bind only weakly to mammalian tubulin, but nevertheless have been classified as potential human carcinogens based on animal studies.1,2 Mancozeb, a dithiocarbamate fungicide, has both mutagenic and teratogenic properties.3,4

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Product label for the fungicide dimethyl 4,4′-o-phenylene bis (3-thioallophanate) with carbamic acid, ethylene bis (dithio)-mangenese zinc complex.

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