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Leisure-Time Physical Activity and Mortality: How Is Sausage Made?—Reply

Urho M. Kujala, MD; Jaakko Kaprio, MD; Seppo Sarna, PhD; Markku Koskenvuo, MD
JAMA. 1998;279(20):1611. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-20-jbk0527.
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In Reply.—Dr Ravenholt inquires whether smoking confounds the relationship between physical activity and mortality. Among our cohort, 17.0% men who were sedentary at baseline died during the follow-up period vs 10.2% of men who occasionally exercised and 5.5% of men who were conditioning exercisers. The respective percentages for women were 7.5%, 5.0%, and 2.9%. To properly assess relationships between variables in our entire study cohort, these data should be given by age and sex, because both are associated with physical activity, smoking habits, and deaths, which would result in very extensive tables. There are earlier studies on this subject on an individual level and the results of individual-based analyses were summarized in our article as a reference for pairwise analyses. Our article focused on pairwise analyses among twins.

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