In Reply.—Dr Amoroso et al suggest that
tobacco use, not available in our study, may have confounded the association
between benzodiazepine use and the risk of motor vehicle crash in the elderly.
Given the lack of an effect with short-acting benzodiazepines, and the fact
that tobacco use is unlikely to be differentially distributed according to
the type of benzodiazepine (long- vs short-acting), confounding by tobacco
use is unlikely to account for our results.
Drs Green and Wintfeld suggest that insufficient information was available
to control for confounding by health status. We used the chronic disease score
to obtain a measure of health status based on patterns of drugs dispensed
in the year prior to the index date.1Thus,
cardiovascular disorders, diabetes, and other chronic conditions and their
severity are taken into account. Moreover, exposure to other drugs with central
nervous system effects, including antidepressants, were controlled for separately
in the analysis. It is unlikely that, after controlling for these accurate
measures of health status, confounding would still be present.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.