Author Contributions: Dr Lok had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Lok, Moist, Hemmelgarn, Tonelli, Dorval, Oliver, Donnelly, Allon, Stanley.
Acquisition of data: Lok, Moist, Hemmelgarn, Tonelli, Vazquez, Dorval, Oliver, Donnelly, Allon.
Analysis and interpretation of data: Lok, Moist, Hemmelgarn, Tonelli, Vazquez, Oliver, Allon, Stanley.
Drafting of the manuscript: Lok, Moist, Hemmelgarn, Tonelli, Oliver, Stanley.
Critical revision of the manuscript for important intellectual content: Lok, Moist, Hemmelgarn, Tonelli, Vazquez, Dorval, Oliver, Donnelly, Allon, Stanley.
Statistical analysis: Lok, Stanley.
Obtained funding: Lok.
Administrative, technical, or material support: Lok, Moist, Vazquez, Dorval, Donnelly, Stanley.
Study supervision: Lok, Moist, Hemmelgarn, Tonelli, Vazquez, Dorval, Donnelly, Allon.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Moist reported serving as a consultant for Amgen and Leo and receiving payment for lectures from Roche and Merck. Dr Dorval reported serving as a board member for Gambro; serving as a consultant for Gambro; receiving grants or grants pending from Gambro and Baxter; and receiving payment for lectures from Gambro and Novartis. Dr Oliver reported receiving author royalties from UpToDate and that he is the sole owner of Oliver Medical Management Inc, which manufactures dialysis-related software. Dr Allon reported receiving a grant and travel support from the University of Alabama at Birmingham. Dr Stanley reported serving as the FISH study's independent statistician and that he served as Executive Director of the Center for Biostatistics and AIDS Research at Harvard School of Public Health before retiring. No other authors reported disclosures.
Funding/Support: This study was supported by peer-reviewed grant funding from the Physician's Services Incorporated Foundation and the Canadian Institutes for Health Research (CIHR). During the study, Drs Lok, Hemmelgarn, and Tonelli were supported by CIHR New Investigator Awards. Dr Lok was also supported by the CIHR Randomized Clinical Trials Mentoring Program. Currently, Drs Hemmelgarn and Tonelli are also supported by Alberta Heritage Foundation for Medical Research Population Scholar Awards; Dr Tonelli is supported by a Government of Canada Research Chair. Dr Allon is supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant K24 DK59818-01. Dr Vazquez is supported by NIDDK grants 5UO1 DK082240 and R34 DK094115.
Role of the Sponsors: Physician's Services Incorporated and CIHR had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Fish Oil Inhibition of Stenosis in Hemodialysis Grafts (FISH) Participating Centers and Principal Investigators: Canada: Toronto and Greater Toronto Area, Ontario: Toronto General Hospital (Charmaine E. Lok); Sunnybrook Health Sciences Centre (Matthew Oliver); St. Michael's Hospital (Sandra Donnelly); Scarborough General Hospital (Tabo Sikaneta and Jason Fung); Credit Valley Hospital (George Wu); Oakville-Trafalgar Hospital (Danny Sapir). Kitchener, Ontario: Grand River Hospital (Tom Liu). London, Ontario: London Health Sciences Centre (Louise Moist). Montreal, Quebec: Charles leMoyne Hospital (Serge Cournoyeur). Moncton, New Brunswick: Dr. Georges-L.-Dumont University Hospital Centre (Marc Dorval). Calgary, Alberta: Foothills Medical Centre (Brenda Hemmelgarn). Edmonton, Alberta: University of Alberta (Marcello Tonelli). United States: Dallas, Texas: University of Texas Southwestern Medical Center (Miguel Vazquez). Birmingham, Alabama: University of Alabama at Birmingham (Michael Allon). Charlottsville, Virginia: University of Virginia (Donald Brophy).
Additional Contributions: We are grateful for the scientific and personal dedication given by each of the investigators, without whom this study would not have been possible. We thank Bruce Holub, PhD (Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, Ontario), for his assistance with the gas-liquid chromatography interpretation to determine omega-3 fatty acid cellular incorporation and study compliance. Dr Holub received no compensation for his contributions.