Author Contributions: Dr Tanabe had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Tanabe, Finkelstein,
Acquisition of data: Tanabe, Lemoine,
Kawasaki, Fujii, Chung, Lauwers, Kulu, Kuruppu, Azoulay, Fuchs.
Analysis and interpretation of data:
Tanabe, Lemoine, Finkelstein, Kawasaki, Fujii, Chung, Lauwers, Muzikansky,
Kuruppu, Lanuti, Goodwin, Azoulay, Fuchs.
Drafting of the manuscript: Tanabe,
Kawasaki, Fujii, Chung, Lanuti, Goodwin, Fuchs.
Critical revision of the manuscript for important intellectual content: Tanabe, Lemoine, Finkelstein, Kawasaki,
Chung, Lauwers, Kulu, Muzikansky, Kuruppu, Azoulay, Fuchs.
Statistical analysis: Tanabe, Finkelstein,
Obtained funding: Tanabe, Fuchs.
Administrative, technical, or material support:
Tanabe, Lemoine, Kawasaki, Fujii, Chung, Lauwers, Kulu, Kuruppu, Goodwin,
Study supervision: Tanabe, Fuchs.
Financial Disclosures: None reported.
Funding/Support: This work was supported by grants 2R01CA76183 (Dr Tanabe), 5P01CA111519 and 2P30 CA06516-43
(Dr Finkelstein and Ms Muzikansky), and AI06993 and DK078772 (Dr Chung)
from the National Institutes of Health; the Massachusetts General Hospital Department of Surgery (Drs Tanabe, Kawasaki, Fujii, Kuruppu,
Lanuti, and Fuchs and Mr Goodwin), Tucker Gosnell Gastrointestinal Cancer Center (Drs Tanabe, Chung, Fuchs), and Fund for Medical Discovery Fellowship (Dr Fuchs); Deutsche Forschungsgemeinschaft (Dr Kulu);
Hirslanden Bern, Berner Viszeralchirurgie (Dr Kulu); Fondation de l'Avenir (Dr Lemoine).
Role of the Sponsor: None of supporting organizations and sponsors played any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We acknowledge and thank Daniel Haber, MD, PhD, and Bruce Chabner, MD, Massachusetts General Hospital Cancer Center for their insightful comments and suggestions,
for which they received no compensation.