Author Contributions: Drs Schetter and Harris had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Schetter,
Leung, Yanaihara, Yuen, Harris.
Acquisition of data: Schetter, Leung,
Sohn, Bowman, Yuen, Chan, Kwong, Au, Liu, Calin, Croce, Harris.
Analysis and interpretation of data:
Schetter, Leung, Sohn, Zanetti, Liu, Croce, Harris.
Drafting of the manuscript: Schetter,
Sohn, Croce, Harris.
Critical revision of the manuscript for important intellectual content: Schetter, Leung, Zanetti, Bowman, Yanaihara,
Yuen, Chan, Kwong, Au, Liu, Calin, Harris.
Statistical analysis: Schetter, Zanetti,
Obtained funding: Leung, Yuen, Chan.
Administrative, technical, or material support:
Leung, Sohn, Bowman, Yuen, Chan, Kwong, Au, Liu.
Study supervision: Harris.
Financial Disclosures: None reported.
Funding/Support: This research was supported by the Intramural Research Program of the National Cancer Institute, Center for Cancer Research, National Institutes of Health.
Drs Leung, Chan, and Yuen were supported by the Research Grants Council of the Hong Kong Special Administrative Region (HKU 7498/06M). Drs Schetter and Zanetti were supported by the Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute.
Role of the Sponsors: The funding agencies had no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; and preparation, review,
or approval of the manuscript.
Additional Contributions: We thank Xin Wang, PhD, Stefan Ambs, PhD, Kensuke Kumamoto, MD, PhD, Ewy Mathe, PhD, and Rosemary Braun, PhD, for helpful discussion; Megan Hames,
BS, and Jin Jen, MD, PhD, for advice on in situ hybridization techniques;
Judith Welsh, BS, for technical assistance; and Dorothea Dudek-Creaven,
MSC, for editorial assistance, all of the Center for Cancer Research,
National Cancer Institute. We thank Kathleen Meyer, BA, Center for Information Technology, National Institutes of Health, for uploading microarray data files to Gene Omnibus Profiles. We also than Raymond Jones, PhD, Audrey Salabes, BS, and John Cottrell, MS, of the University of Maryland Medical Center, the clinicians of the departments of surgery and pathology in Queen Mary Hospital, at University of Maryland Hospital, and at the Baltimore Veterans Administration Medical Center for contributions to this study.
This article was corrected online for typographical errors on 10/17/2008.