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CYP2C19 Genotype and Cardiovascular Events

Gerasimos Siasos, MD, MSc, PhD; Dimitris Tousoulis, MD, PhD; Christodoulos Stefanadis, MD, PhD
JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.445.
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To the Editor: The article by Dr Holmes and colleagues1 appraised the evidence on the association between CYP2C19 genotype and clopidogrel response through a systematic review and meta-analysis. Their results showed that although there was an association between the CYP2C19 genotype and clopidogrel responsiveness, overall there was no significant association of genotype with cardiovascular events.

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April 11, 2012
Alan R. Shuldiner, MD; Mark R. Vesely, MD; Adam Fisch, BS
JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.443.
April 11, 2012
Jessica L. Mega, MD, MPH; Eric J. Topol, MD; Marc S. Sabatine, MD, MPH
JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.444.
April 11, 2012
Michael V. Holmes, MBBS, MSc; Aroon D. Hingorani, FRCP, PhD; Juan P. Casas, MD, PhD
JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.446.
April 11, 2012
Steven E. Nissen, MD
JAMA. 2012;307(14):1482-1485. doi:10.1001/jama.2012.447.
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