In a Clinical Crossroads article published in January 2009,1 Bradley Van Voorhis, MD, discussed the epidemiology, management, and treatment of uterine fibroids. The patient, Ms P, was a 41-year-old woman with recurrent uterine fibroids, menorrhagia, anemia, and fatigue since age 30 years. Because of intractable symptoms, at age 35 years she underwent a myomectomy. Two years later, Ms P's fatigue returned, as did her heavy periods. Repeat ultrasound at that time showed multiple large fibroids, which continued to grow during the subsequent 2 years. Given her persistent symptoms, Ms P wished to consider treatment but expressed an interest in options that would allow her to retain her uterus.