The goal of comparative effectiveness research (CER) is to provide patients, their advocates and caregivers, health care professionals, federal officials, policy makers, and payers with evidence-based information to make informed health care decisions.1,2 Previously, CER studies were designed by researchers and had relatively little input from patients. Patient engagement has rapidly gained acceptance as crucial to the successful translation of CER for all interested parties.3 Experiences with patient engagement in research, including community-based participatory research,4 suggest that success hinges on patients being interested and emotionally involved in the research question and understanding their role in the CER process.
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