On July 25, 2011, the Department of Health and Human Services published an advance notice of proposed rule making, outlining potential changes to the federal regulations overseeing human subjects research.1 These regulations, known since 1991 as “the Common Rule,” have been effective in ensuring that most human research in this country is reviewed prospectively by an institutional review board (IRB) charged with determining that risks of proposed research are minimized and acceptable and also ensuring that individual participants provide informed consent for most types of research before participation.
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