Financial Disclosure: Dr Eisenberg has received
honoraria for educational lectures relating to the epidemiology of complementary
therapy use, ongoing research in this area at Harvard Medical School, and
national trends in complementary medicine research but has neither spoken
on the topic of Ayurveda or the efficacy, safety, or toxicity of Ayurveda,
or received grant support (federal or private) for investigations of Ayurvedic
Author Contributions: Dr Saper had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Saper, Kales, Burns,
Eisenberg, Davis, Phillips.
Acquisition of data: Saper, Paquin.
Analysis and interpretation of data: Saper,
Kales, Burns, Eisenberg, Davis.
Drafting of the manuscript: Saper, Kales, Burns.
Critical revision of the manuscript for important
intellectual content: Saper, Kales, Paquin, Burns, Eisenberg, Davis,
Statistical analysis: Saper, Davis.
Obtained funding: Saper, Eisenberg, Phillips.
Administrative, technical, or material support:
Saper, Kales, Paquin.
Study supervision: Saper, Burns, Eisenberg,
Funding/Support: Dr Saper was supported by
an Institutional National Research Service Award for training in Alternative
Medicine Research (T32 AT00051) from the National Center for Complementary
and Alternative Medicine (NCCAM), National Institutes of Health, Bethesda,
Md. Dr Phillips is supported by a Mid-Career Investigator Award (K24 AT00589)
from NCCAM. Herbal products were purchased with funds from the Division for
Research and Education in Complementary and Integrative Medical Therapies
of Harvard Medical School.
Role of the Sponsor: Harvard Medical School
had no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; or preparation, review, or approval
of the manuscript for submission.
Disclaimer: The content of this article is
solely the responsibility of the authors and does not necessarily represent
the official views of the NCCAM, the National Institutes of Health, or the
US Environmental Protection Agency.
Acknowledgment: We gratefully thank Mary Beth
Hamel, MD, MPH, and Michael Shannon, MD, for their review of an earlier version
of the manuscript; DavidSolondz, BSE, for assistance with sample collection;
Brian Ambrefe, RPh, CDE, for donation of sample vials; Naseem Hines, PhD,
for label translation; Anusha Seghal, BAMS, for helpful discussions regarding
Ayurveda; and Nadia Khouri for editing.