Author Contributions: Drs Bernardi and Camporese had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bernardi, Piccioli, Prandoni.
Acquisition of data: Bernardi, Camporese, Siragusa, Imberti, Berchio, Ghirarduzzi, Verlato, Anastasio, Prati,Pesavento, Bova, Maltempi, Zanatta, Cogo, Cappelli, Bucherini, Cuppini.
Analysis and interpretation of data: Bernardi, Camporese, Büller, Imberti, Prati, Noventa, Prandoni.
Drafting of the manuscript: Bernardi,Camporese, Büller, Berchio, Noventa, Prandoni.
Critical revision of the manuscript for important intellectual content: Bernardi, Camporese, Büller, Siragusa, Imberti, Ghirarduzzi, Verlato, Anastasio, Prati, Piccioli, Pesavento, Bova, Maltempi, Zanatta, Cogo, Cappelli, Bucherini, Cuppini, Noventa, Prandoni.
Statistical analysis: Bernardi, Noventa.
Administrative, technical, or material support: Bernardi, Camporese.
Study supervision: Bernardi, Camporese, Büller, Imberti, Verlato, Prati, Piccioli, Pesavento, Noventa,Prandoni.
Financial Disclosures: None reported.
Members of the Erasmus Study Group (Italy): Angiology Unit, University Hospital, Padua: Laura Zotta, MD, Francesca Franz, MD, Claudia Chiarion, MD, Mariateresa Nardi, MD, Giuseppe M. Andreozzi, MD; Service of Haemostasis and Thrombosis, University Hospital, Palermo: Alessandra Malato, MD, Lucio Lo Coco, MD, Glauco Milio, MD, Oreste Cormaci, MD; Center for Haemostasis and Thrombosis, Department of Emergency and Accident Medicine, Civic Hospital, Piacenza: Pietro Cavallotti, MD, Sergio Orlando, MD; Department of Emergency and Accident Medicine, S Giovanni Battista Hospital, Torino: Elio Rolfo, MD, Carlo Valenzano, MD; Angiology Unit, Department of Internal Medicine, S Maria Nuova Hospital, Reggio Emilia: Matteo Iotti, MD, Maria L. Cattabiani, MD; Department of Angiology, Civic Hospital, Castelfranco Veneto: Adriana Visonà, MD, Francesca Salsa, MD, Antonio Pagnan, MD; Department of Medicine, Civic Hospital, Cosenza: Roberto Ricchio, MD, Alfonso Noto, MD; Department of Surgical Sciences, S Carlo Borromeo Hospital, Milan: Pier G. Settembrini, MD; Department of Internal Medicine, Civic Hospital, Vittorio Veneto: Massimo Santonastaso, MD, Domenico Mognol, MD; Department of Internal, Cardiovascular, and Geriatric Medicine, Policlinico “Le Scotte,” Siena: Maurizio Bicchi, MD, Francesca Maggi, MD; Department of Internal Medicine, Civic Hospital, Rovigo: Stefano Zamboni, MD; Department of Medical and Surgical Sciences, University, Padua: Ugo Baccaglini, MD, Giuseppe Spreafico, MD.
Funding/Support: This study project was awarded to Dr Bernardi by SISET (Società Italiana per lo Studio dell’Emostasi e della Trombosi). The AGEN Biomedical Ltd (Brisbane, Australia) provided the D-dimer testing kits free-of-charge.
Role of the Sponsor: The AGEN Biomedical Ltd had no role in the design and conduct of the study, in the collection, analysis, or interpretation of the data, or in the preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented in part as an oral communication at the XXIst Congress of the International Society on Thrombosis and Haemostasis; July 6-12,2007; Geneva, Switzerland.