Author Contributions: Dr Holmes had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Holmes, Hingorani, Casas.
Acquisition of data: Holmes, Shah.
Analysis and interpretation of data: Holmes, Perel, Shah, Hingorani, Casas.
Drafting of the manuscript: Holmes, Casas, Hingorani.
Critical revision of the manuscript for important intellectual content: Holmes, Perel, Shah, Hingorani, Casas.
Statistical analysis: Holmes, Casas.
Obtained funding: Casas, Hingorani.
Administrative, technical, or material support: Shah.
Study supervision: Hingorani, Casas.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Hingorani was previously the principal investigator receipt of a Biomarker Award from the Medical Research Council with Pfizer as an Industrial partner. This award was to investigate complement factor H in the prediction or pathogenesis of age-related macular disease or coronary heart disease. The award is now closed. Dr Hingorani has provided free advice to colleagues at University College London on the design and analysis of pharmacogenetic studies, including an analysis funded in part by Celera through a contract with University College London and Medical Research Council. All other coauthors reported no conflicts of interest.
Funding/Support: Dr Holmes is supported by a Medical Research Council Population Health Scientist Fellowship (G0802432); Dr Hingorani was supported by a British Heart Foundation Senior Research Fellowship (FS 05/125) at the time this work was conducted. Dr Hingorani is co-investigator on a National Institute for Health Research program grant (RP-PG-0407-10314).
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the Medical Research Council or the British Heart Foundation.