Author Contributions: Dr Dupuis-Girod had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Dupuis-Girod, Ginon, Saurin, Decullier, Ternant, Faure.
Acquisition of data: Dupuis-Girod, Ginon, Saurin, Marion, Guillot, Carette, Gilbert-Dussardier, Hatron, Lacombe, Lorcerie, Rivière, Corre, Giraud, Ternant, Valette, Plauchu, Faure.
Analysis and interpretation of data: Dupuis-Girod, Ginon, Decullier, Roux, Bailly, Paintaud, Ternant, Faure.
Drafting of the manuscript: Dupuis-Girod, Ginon, Corre, Ternant.
Critical revision of the manuscript for important intellectual content: Dupuis-Girod, Ginon, Saurin, Marion, Guillot, Decullier, Roux, Carette, Gilbert-Dussardier, Hatron, Lacombe, Lorcerie, Rivière, Giraud, Bailly, Paintaud, Ternant, Valette, Plauchu, Faure.
Statistical analysis: Dupuis-Girod, Decullier, Roux, Paintaud, Ternant.
Obtained funding: Dupuis-Girod, Hatron, Plauchu.
Administrative, technical, or material support: Dupuis-Girod, Giraud, Paintaud, Ternant, Valette, Plauchu, Faure.
Study supervision: Dupuis-Girod, Ginon, Saurin, Decullier, Plauchu.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Paintaud reported being a consultant for Laboratoires Français du Fractionnement et des Biotechnologies (LFB), Roche Pharma, Wyeth, Janssen, and Pierre-Fabre Laboratories. No other disclosures were reported.
Funding/Support: This work was financed by the institution (Hospices Civils de Lyon) with a grant supported by the National Research Program (PHRC 2009 and 2010) and by Roche Laboratories, which also provided the drug. Measurement of bevacizumab serum concentrations were carried out within the CePiBAc platform. CePiBAc is cofinanced by the European Union. Europe is committed to the region Centre with the European Regional Development Fund.
Role of the Sponsor: The funding organization (National Research Program) and Roche Laboratories had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank all the patients who participated in this study, the association of patients, and all the members of the French HHT Network, as well as Anne-Emmanuelle Fargeton, for their technical help. No one received compensation for the contributions.