Author Contributions: Dr Engel had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Engel, McDermott, Wiebe, Langfitt, Dewar, Sperling, Gardiner, Erba, Fried, Jacobs, Kieburtz.
Acquisition of data: Engel, Wiebe, Stern, Dewar, Sperling, Fried, Vinters, Mintzer.
Analysis and interpretation of data: Engel, McDermott, Wiebe, Langfitt, Stern, Sperling, Fried, Mintzer, Kieburtz.
Drafting of the manuscript: Engel, Wiebe, Langfitt, Stern, Sperling, Fried, Kieburtz.
Critical revision of the manuscript for important intellectual content: Engel, McDermott, Wiebe, Langfitt, Stern, Dewar, Sperling, Gardiner, Erba, Fried, Jacobs, Vinters, Mintzer, Kieburtz.
Statistical analysis: McDermott, Wiebe, Langfitt.
Obtained funding: Engel, Langfitt, Jacobs, Vinters, Kieburtz.
Administrative, technical, or material support: Engel, Stern, Dewar, Gardiner, Fried, Jacobs, Kieburtz.
Study supervision: Engel, Wiebe, Dewar, Erba, Fried, Kieburtz.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Engel, Stern, Sperling, and Mintzer and Mss Gardiner and Jacobs report receipt of an institutional grant from the National Institutes of Health (NIH); and Drs McDermott, Langfitt, and Fried report receipt of an institutional grant from the National Institute of Neurological Disorders and Stroke (NINDS). Dr Engel reports receipt of consultancy fees from Medtronics, Valeant, Acorda, the US Food and Drug Administration, Best Doctors; receipt of fees to the institution for expert testimony; receipt of lecture/speakers bureau fees from Esai, Johnson & Johnson, Novartis, Lippincott; receipt of patent fees (WO2009/123734A1 and WO2009/123735A1); receipt of royalties from Wolters Kluwer, Wiley Blackwell, Elsevier, MedLink; and receipt of fees for travel accommodations/meeting expenses from UCB Pharmaceuticals. Dr McDermott reports receipt of fees to the institution for travel accommodations/meeting expenses for this study from NINDS, fees to the institution for consultancy from Boehringer-Ingelheim and Pfizer; receipt of consultancy fees from Teva Pharmaceutical Industries, Smith and Nephew, Synosia, Impax Pharmaceuticals; grant support or pending grant support to the institution from Medivation, NeuroSearch Sweden AB, Boehringer-Ingelheim, Pfizer. Dr Wiebe reports grant support from NINDS, fees for travel accommodations/meeting expenses from NINDS; employment with the University of Calgary; grant support or pending grant support from the Canadian Institutes of Health Research; fees for travel accommodations/meeting expenses from the International League Against Epilepsy. Dr Langfitt reports receipt of fees for travel accommodations/meeting expenses from NIH; consultancy fees from NINDS, UCSF/Elekta, Northern Illinois University, University of Cincinnatti, NIH CSR (Center for Scientific Review); grant support or pending grant support from NINDS and the Agency for Healthcare Research and Quality; fees to the institution for development of educational presentations from NIH. Dr Stern reports receipt of fees for travel accommodations/meeting expenses from NIH. Dr Sperling reports receipt of consultancy fees from UCB, Vertex, Sunovion; grant support or pending grant support from NIH, UCP, Vertex, Eisai, Sunovion, Medtronics, Neuropace, SK Life Sciences, Novartis, Neuronex; lecture/speakers bureau fees from UCB; other fees as associate editor from Epilepsia. Mss Gardiner and Dewar and Dr Erba report no disclosures.
Funding/Support: This study was supported by the National Institutes of Health (grant numbers R21 NS37897 and U01 NS42372).
Role of the Sponsor: This study was funded as a cooperative agreement with the National Institute of Neurological Disorders and Stroke, whose representative (Ms Jacobs) was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, and approval of the manuscript. The study's biostatistician (Dr McDermott) from the University of Rochester performed or supervised, and is responsible for, all statistical analyses for this study.
ERSET Study Group: David Blum, MD, Steven Chung, MD, and David Treiman, MD, Barrow Neurological Institute, Phoenix, AZ; Erasmo A. Passaro, MD, Bayfront Medical Center, St Petersburg, FL; David R. Browne, MD, School of Medicine, Boston University, Boston, MA; Nancy Foldvary-Schaefer, DO, MS, Cleveland Clinic Neurological Institute, Cleveland, OH; Robert Goodman, MD, PhD, W. Allen Hauser, MD, and Martha J. Morrell, MD, Columbia University, New York, NY; Thomas R. Henry, MD, Raghuveer Krishna Halkar, MD, and Patricia A. Hudgins, MD, FACR, Emory University, Atlanta, GA; Andrew J. Cole, MD, FRCP(C), and Daniel B. Hoch, MD, PhD, Harvard Medical School and Massachusetts General Hospital, Boston, MA; Steven C. Schachter, MD, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; Vicenta Salanova, MD, FAAN, Indiana University, Indianapolis; Gregory L. Krauss, MD, Johns Hopkins University, Baltimore, MD; Thaddeus S. Walczak, MD, MINCEP Epilepsy Care, Minneapolis, MN; Prashanthi Boppana, MD, Northwestern University, Evanston, IL; L. James Willmore, MD, St Louis University, St Louis, MO; John J. Barry, MD, Robert S. Fisher, MD, PhD, and Michael W. Risinger, MD, Stanford University, Stanford, CA; Robert Beach, MD, PhD, FAAN, State University of New York, Syracuse; Diana A. Kraemer, MD, and David G. Vossler, MD, FAAN, Swedish Medical Center, Seattle, WA; Rochelle Caplan, MD, William E. Cunningham, MD, PhD, Faustino Lopez-Rodriguez, MD, PhD, Gary Mathern, MD, W. Donald Shields, MD, Jason R. Soss, MD, Karleen Swarztrauber, MD, PhD, and Barbara G. Vickrey, MD, MPH, University of California, Los Angeles; Henry A. Buchtel, PhD, Daniela N. Minecan, MD, and Oren Sagher, MD, University of Michigan, Ann Arbor; Jerry J. Shih, MD, University of New Mexico, Albuquerque; Jacqueline A. French, MD, University of Pennsylvania, Philadelphia; Michel Berg, MD, James Burchfiel, PhD, Catherine Covert, MA, Arthur Watts, BS, and Earl Westerlund, University of Rochester, Rochester, NY; Paul C. Van Ness, MD, University of Texas Southwestern Medical Center, Dallas; Nathan B. Fountain, MD, University of Virginia, Charlottesville; Bassel Abou-Khalil, MD, Vanderbilt University Medical Center, Nashville, TN; John M. (Jack) Pellock, MD, Virginia Commonwealth University, Richmond; Frank Gilliam, MD, MPH, Washington University, St Louis, MO; and Dennis Spencer, MD, Yale University School of Medicine, New Haven, CT.
Additional Contributions: Analyses of the cognitive outcomes were completed by Neil Osuch, MS, in partial fulfillment of a master's degree in medical statistics at the University of Rochester. Hua He, PhD, performed the sensitivity analysis of the primary outcome variable using multiple imputation. These individuals were not compensated for their contributions to this article.
This article was corrected for errors on March 13, 2012.