Author Contributions: Dr Garbutt had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Garbutt, Spitznagel, Piccirillo.
Acquisition of data: Garbutt, Banister.
Analysis and interpretation of data: Garbutt, Spitznagel, Piccirillo.
Drafting of the manuscript: Garbutt, Spitznagel.
Critical revision of manuscript for important intellectual content: Garbutt, Banister, Spitznagel, Piccirillo.
Statistical analysis: Spitznagel.
Obtaining funding: Garbutt, Spitznagel.
Administrative, technical, or material support: Banister.
Study supervision: Garbutt, Banister.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Piccirillo reported that he has received financial compensation for expert testimony and review of medical records related to litigation surrounding delay in diagnosis for cancer from Carey Perkins LLP and surrounding complications of sleep apnea from Attorney Duncan E. Ragsdale; has grants pending with the National Institutes of Health, the Department of Defense, and the Federal Emergency Management Agency; has received honoraria from Emory University and New York University for invited speaker positions for grand rounds; has received royalties for the Sinonasal Outcome Test; and is chair of data and safety monitoring boards for Apnex Medical and the National Institutes of Health, National Institute on Deafness and Other Communication Disorders. No other author reported disclosures.
Funding/Support: This study was funded by grant U01-AI064655-01A1 from the National Institute of Allergy and Infectious Diseases.
Role of the Sponsor: The National Institute of Allergy and Infectious Diseases did not have a role in the design and conduct of the study; in the collection, management, analysis, or interpretation of the data; or in the preparation, review, or approval of the manuscript.
Online-Only Material: The Author Video Interview is available here.
Additional Contributions: We thank all of the patients who participated in this study; the physicians, nurses, and staff at Associated Internists Inc, Baker Medical Group, Bi-State Medical Consultants Inc, Esse Health (Richmond Heights), Family Care Health Centers, and the Habif Health and Wellness Center at Washington University in St Louis; Susan Colbert-Threats, MD; C. Scott Molden, MD; Wanda Terrell, MD; and Willowbrook Medical Center who referred patients to the study; members of the data and safety monitoring board (Walton Sumner, MD, Thomas Bailey, MD, Fuad Baroody, MD, and Nan Lin, PhD); and Farukh M. Khambaty, PhD, at the Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases for programmatic support. None of the persons listed received compensation for their contributions.