Author Contributions: Dr Bolton had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bolton, Pharoah.
Acquisition of data: Bolton, Chenevix-Trench, Goh, Sadetzki, Ramus, Karlan, Lambrechts, Despierre, Barrowdale, McGuffog, Healey, Easton, Sinilnikova, Benítez, García, Neuhausen, Gail, Hartge, Peock, Frost, Evans, Eeles, Godwin, Daly, Kwong, Ma, Lázaro, Blanco, Montagna, D’Andrea, Nicoletto, Johnatty, Kjær, Jensen, Høgdall, Goode, Fridley, Loud, Greene, Mai, Chetrit, Lubin, Hirsh-Yechezkel, Glendon, Andrulis, Toland, Senter, Gore, Gourley, Michie, Song, Tyrer, Whittemore, McGuire, Sieh, Kristoffersson, Olsson, Borg, Levine, Steele, Beattie, Chan, Nussbaum, Moysich, Gross, Cass, Walsh, Li, Leuchter, Gordon, Garcia-Closas, Gayther, Chanock, Antoniou, Pharoah.
Analysis and interpretation of data: Bolton, Pharoah.
Drafting of the manuscript: Bolton, Gayther, Pharoah.
Critical revision of the manuscript for important intellectual content: Bolton, Chenevix-Trench, Goh, Sadetzki, Ramus, Karlan, Lambrechts, Despierre, Barrowdale, McGuffog, Healey, Easton, Sinilnikova, Benítez, García, Neuhausen, Gail, Hartge, Peock, Frost, Evans, Eeles, Godwin, Daly, Kwong, Ma, Lázaro, Blanco, Montagna, D’Andrea, Nicoletto, Johnatty, Kjær, Jensen, Høgdall, Goode, Fridley, Loud, Greene, Mai, Chetrit, Lubin, Hirsh-Yechezkel, Glendon, Andrulis, Toland, Senter, Gore, Gourley, Michie, Song, Tyrer, Whittemore, McGuire, Sieh, Kristoffersson, Olsson, Borg, Levine, Steele, Beattie, Chan, Nussbaum, Moysich, Gross, Cass, Walsh, Li, Leuchter, Gordon, Garcia-Closas, Gayther, Chanock, Antoniou, Pharoah.
Statistical analysis: Bolton, Goh, Gail, Tyrer, Pharoah.
Obtained funding: Chenevix-Trench, Easton, Gayther, Chanock, Antoniou, Pharoah.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Easton reported serving on the board of Genome Canada SIAC. Dr Godwin reported receiving consultancy fees from TetraLogic and Pfizer and grants from Merck, TetraLogic, and Millennium. Dr Gourley reported receiving consultancy fees from Roche, Schering-Plough, Merck Sharpe Dohme, Chugia, GlaxoSmithKline, and PharmaMar; receiving grants from AstraZeneca, GlaxoSmithKline, and Cyclacel; serving as a board member for Roche, Schering-Plough, and Chugai; receiving payment for lectures and educational presentations from Chugai and Merck Sharpe Dohme; and receiving compensation for travel expenses from Schering-Plough, Chugai, PharmaMar, Roche, and Boehringer Ingelheim. Dr Olsson reported receiving payment for lectures from NovoNordisk. Dr Nussbaum reported serving on the board and receiving consultancy fees and stock from Complete Genomics Inc. No other authors reported any disclosures.
A full list of principal investigators and participating centers for EMBRACE has been published (Hum Mol Genet. 2010;19(14):2886-2897).
Members of the kConFab Investigators:Peter MacCallum Cancer Center, East Melbourne, Australia: Stephen Fox, MD; Ian Campbell, PhD; Melissa Brown, PhD; Gerda Evans; Judy Kirk: Westmead Hospital, MD, PhD; Sunil Lakhani, MD; Geoff Lindeman, MD, PhD; Gillian Mitchell, MD, PhD; Kelly Phillips, MD; Melanie Price, PhD; Christobel Saunders, MD; Mandy Spurdle, PhD; Graeme Suthers, MD, PhD; Roger Milne, PhD.
A full list of principal investigators and participating centers for The Cancer Genome Atlas Research Network has been published (Nature. 2011;474(7353):609-615).
Funding/Support: This work was supported by grants C490/A10119, C490/A10124, C1287/A10118, C1287/A11990, C5047/A8385 from Cancer Research UK; grants 223175, HEALTH-F2-2009-223175 from the Edinburgh Experimental Cancer Medicine Center, the European Community's Seventh Framework Program; grants PS09/01094 and PI081120 from the Fondo de Investigación Sanitaria; grant AP-8101-2010 from the Fundación Mutua Madrileña; grants CA 74415, CA 61126-03, R01-CA 61107, R01-CA 122443, P50 CA 136393, P01 CA 130818, 2P50 CA 058207, and the Intramural Research Program of the National Cancer Institute, DCEG from the Melville Trust for the Care and Cure of Cancer, National Institutes of Health; the Nationaal Kankerplan–Actie 29' of Belgium; the NHMRC of Australia; the National Breast Cancer Foundation of Australia, Cancer Australia (628333); the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia; the Cancer Foundation of Western Australia; the Scottish Funding Council; the Scottish Chief Scientist's Office; the Manchester NIHR Biomedical Research Center; Minnesota Ovarian Cancer Alliance; Fred C. and Katherine B. Andersen Foundation; Mermaid 1 project; the Danish Cancer Society; Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero della Salute (“Progetto Tumori Femminili” and RFPS 2006-5-341353, ACC2/R6.9”); the Israeli Cancer Association; the Helen Diller Family Comprehensive Cancer Center at University of California San Francisco; the Avon Foundation; The Hong Kong Hereditary Breast Cancer Family Registry and the Dr Ellen Li Charitable Foundation; and service grants NO2-CP-11019-50 and N02-CP-65504 (with Westat, Inc, Rockville, MD) through the National Cancer Institute; Asociación Española Contra el Cáncer, Spanish Health Research Fund; Carlos III Health Institute; and grants ISCIIIRETIC RD06/0020/1051, PI10/01422, PI10/31488, and 2009SGR290 from the Catalan Health Institute and Autonomous Government of Catalonia. Dr Karlan is supported by funding (grant SIOP-06-258-06-COUN) from the American Cancer Society, Clinical Research Professorship. Dr García is the recipient of a Miguel Servet contract from the Instituto de Salud Carlos III. Dr Antoniou is a Cancer Research UK Senior Cancer Research Fellow.
Role of the Sponsors: None of the sponsors described above had any role in the design or conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank all the patients and families who took part in the component studies and the many individuals who have made these studies possible. John Stratton, PhD, and Vickie Basham, BA, provided help in collecting and managing data from the UK Gilda Radner Familial Ovarian Cancer Registry study. Heather Thorne, BSci (Professional Diploma in Clinical Research), and Eveline Niedermayr, BSc (G.Dip. Information Management, G.Dip. Software Development), provided help in collecting and managing data for the Kathleen Cuningham Consortium for Research into Familial Breast Cancer study. None of the individuals acknowledged herein received specific compensation for their role in the manuscript.