Author Contribution: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Meltzer and Eng contributed equally to the manuscript.
Study concept and design: Orloff, He, Heald, Romigh, Meltzer, Eng.
Acquisition of data: Peterson, He, Ganapathi, Heald, Yang, Bebek, Song, Wu, David, Cheng, Meltzer.
Analysis and interpretation of data: Orloff, He, Ganapathi, Bebek, Romigh, Meltzer, Eng.
Drafting of the manuscript: Orloff, He, Bebek, David, Meltzer, Eng.
Critical revision of the manuscript for important intellectual content: Orloff, Peterson, He, Ganapathi, Heald, Yang, Bebek, Romigh, Song, Wu, David, Cheng, Meltzer, Eng.
Statistical analysis: Orloff, He, Bebek, Eng.
Obtained funding: Meltzer, Eng.
Administrative, technical, or material support: Peterson, He, Ganapathi, Heald, Yang, Romigh, Song, Wu, David, Cheng, Meltzer, Eng.
Study supervision: Meltzer, Eng.
Accruing research subjects documented and verified phenotypes and/or participated in material acquisition: Heald, Song, Wu, David, Cheng, Meltzer, Eng.
Genetic counselor coordinator: Heald.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Bebek reported receiving grant funding from the National Institutes of Health (NIH). Dr Meltzer reported receiving grants from the National Cancer Institute (NCI) and the National Institute of Diabetes and Digestive and Kidney Diseases; and travel, accommodations, and meeting expenses from Hong Kong University. Dr Eng reported receiving grants from the NCI and Rudy Endowment. All other authors reported no financial disclosures.
Funding/Support: This work was funded in part by the M. Frank and Margaret Domiter Rudy Endowment of the Cleveland Clinic Taussig Cancer Institute and grants CA30722, DK087454, CA146799, and CA133012 from the NCI/NIH (S.J.M. and C.E.). Dr Meltzer is the Harry & Betty Myerberg/Thomas R. Hendrix Professor of Gastroenterology and was funded in part by the Esophageal Cancer Research Fund at the Johns Hopkins University School of Medicine. Dr Eng was a recipient of the Doris Duke Distinguished Clinical Scientist Award, is an American Cancer Society Clinical Research Professor generously funded in part by the F.M. Kirby Foundation, holds the Sondra J. & Stephen R. Hardis Chair in Cancer Genomic Medicine at the Cleveland Clinic, and is an honorary fellow of the Cancer Research UK Human Cancer Genetics Research Group, University of Cambridge, Cambridge, England.
Role of the Sponsors: The funding organizations had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.