Author Contributions: Dr Wainwright had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Wainwright, Byrnes, Carlin, Robertson.
Acquisition of data: Wainwright, Armstrong, Byrnes, Cheney, Cooper, Robertson.
Analysis and interpretation of data: Wainwright, Vidmar, Armstrong, Cheney, Grimwood, Moodie, Robertson, Tiddens.
Drafting of the manuscript: Wainwright, Byrnes, Carlin, Cooper, Grimwood, Robertson, Tiddens.
Critical revision of the manuscript for important intellectual content: Wainwright, Vidmar, Armstrong, Byrnes, Carlin, Cheney, Cooper, Grimwood, Moodie, Robertson.
Statistical analysis: Wainwright, Vidmar, Carlin.
Obtained funding: Wainwright, Byrnes, Carlin.
Administrative, technical, or material support: Vidmar, Armstrong, Byrnes, Cheney, Robertson.
Study supervision: Wainwright, Armstrong, Carlin, Robertson.
Management of project in New Zealand, including ethics: Byrnes.
Microbiological advice: Grimwood.
Image analysis: Tiddens.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Wainwright reported receiving travel grants from North American Cystic Fibrosis Foundation and from the European Cystic Fibrosis Society, funding from Novartis to cover an extra night at European CF Conference 2010, travel and accommodation expenses from the UK CF Trust, and travel and accommodation expenses from the University of Miami; serving as a board member for Novartis Pharma; serving as a consultant for Vertex Pharmaceuticals Inc, Gilead Sciences Inc, and Inspire Pharmaceuticals Inc; receiving grants or grants pending from GlaxoSmithKline, Boehringer-Ingelheim, Vertex Pharmaceuticals Inc, and Insmed Inc; and receiving payment for lectures (including speakers bureau) from Novartis Pharma. Dr Byrnes reported receiving grant support from the New Zealand Health Research Council and the Faculty Research Development Fund (University of Auckland); and receiving travel support from the National Health and Medical Research Council (Australia). Dr Carlin reported receiving review activities fees from the Royal Children's Hospital Queensland. Dr Cooper reported serving as a board member for Pharmaxis Pty Ltd; and receiving grants or grants pending from Vertex Pharmaceuticals Inc, Inspire Pharmaceuticals Inc, and Gilead Sciences Inc. Dr Robertson reported serving as a consultant on advisory boards for Glaxo Seretide and Singulair; and receiving grants or grants pending from the National Health and Medical Research Council. Dr Tiddens reported serving as a consultant for Gilead Sciences Inc, Vertex Pharmaceuticals Inc, and Inspire Pharmaceuticals Inc; receiving grants or grants pending from Gilead Sciences Inc; and receiving payment for lectures from Roche. No other authors reported disclosures.
Role of the Sponsors: The National Health and Medical Research Council, the Royal Children's Hospital Foundation, Pathogenesis Corporation, Chiron Corporation, and Novartis Pharmaceuticals Inc had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
ACFBAL Study Investigators Group:Brisbane, Australia: *Claire E. Wainwright, MBBS, MD (Queensland Children's Medical Research Institute and The University of Queensland), *Keith Grimwood, MBChB, MD (Queensland Children's Medical Research Institute), *Paul W. Francis, MBBS(Hons), MD (Royal Children's Hospital), *Carolyn Dakin, MBBS, MPH, PhD (Mater Children's Hospital), Joyce Cheney, BA, MAppSc(Research) (Queensland Children's Medical Research Institute and The University of Queensland), ‡Narelle George, BSc, MSc, GCM (Pathology Queensland). Melbourne, Australia: *John B. Carlin, BSc, PhD (Murdoch Children's Research Institute), *Colin F. Robertson, MBBS, MSc, MD (Royal Children's Hospital), Suzanna Vidmar, BSc(Hon) (Murdoch Children's Research Institute), ‡Rosemary Carzino, BScHons (Royal Children's Hospital), ‡Marj Moodie, BA(Hon), DrPH, (Deakin University), *‡Robert Carter, BA(Hons), MAdminSt, Grad Dip Epi & Pop Health, PhD (Deakin University), *David S. Armstrong, MBChB, MD (Monash Medical Centre). Sydney, Australia: *Peter J. Cooper, BSc, MBChB (The Children's Hospital at Westmead), Karen McKay (The Children's Hospital at Westmead). Adelaide, Australia: *A. (James) Martin, MBChB (with distinction) (Womens & Children's Hospital). Newcastle, Australia: *Bruce Whitehead, MBBS (John Hunter Children's Hospital). Auckland, New Zealand: *Catherine A. Byrnes, MBChB, MD (Starship Children's Hospital). Rotterdam, the Netherlands: *Harm A. Tiddens, MD, PhD (Erasmus Medical Centre), Karla Graniel, MD, Krista Gerbrands, MD, Lauren Mott, MBBS(Hons)/BMedSci(Hons). *Principal investigator or director. ‡Received part or full salary from NHMRC Grant or RCH Foundation funding.
Additional Contributions: We are indebted to all current and former clinical and research staff from Starship Children's Hospital, Auckland (‡Jan Tate, BHlthSc[Nsg]); The Royal Children's Hospital, Brisbane (I. Brent Masters, MBBS, PhD, ‡Nicholas Gailer, BCreative Industries, Debbie Watson, BAppSciMedRadTech, GradCertRadiographic Practice); The Children's Hospital at Westmead (‡Merilyn McArthur, RN, Sam Forbes RN, Hiran Selvadurai, MBBS, PhD, Susan Towns, MBBS, MMH, Peter van Asperen, MBBS, MD); Royal Children's Hospital, Melbourne (‡Johanna Kappers, BNurs, ‡Sally Sheridan, RN, John Massie, MBBS(Hons), DCH, PhD, Sarath Ranganathan, MBChB, PhD, Phil Robinson, BMedSc, MBBS, MD, PhD); Women's & Children's Hospital, Adelaide (Greg Smith, MBBS); Mater Children's Hospital, Brisbane (Ian Robertson, MBBS, DCH, Margaret Harris, MBBS, ‡Katrina Jess, RN, ‡Peta Yarrow, RN); Cairns Base Hospital (Ross Messer, MBBS); Toowoomba Base Hospital (Jeff Prebble, MBBS); Townsville General Hospital (William Frischman, MBBS); Mackay Base Hospital (Michael Williams, MBBS, MMedSci); Royal Darwin Hospital (Paul Bauert, BSc, MBBS); Deakin University, Melbourne (Anita Lal, BEc, MPH); Erasmus Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands (Els Van Der Wiel, RN). ‡Received part or full salary from NHMRC Grant or RCH Foundation funding. We thank the data and safety monitoring committee: Peter O’Rourke, BSc(Hons), BA(Hons), PhD, GCEd (Queensland Institute of Medical Research, Brisbane); Scott Bell, MBBS, MD (Thoracic Medicine, The Prince Charles Hospital, Brisbane); Ross Shepherd, MBBS, MD (Queensland Institute of Medical Research, Brisbane, and Washington University School of Medicine). In particular, we express our gratitude to all the patients and their families for making this study possible. None of the individuals acknowledged received any compensation for their contributions, except where indicated (‡).
This article was corrected for error on July 2, 2014.