Published Online: December 12, 2011. doi:10.1001/jama.2011.1830
Author Contributions: Dr Habel had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Habel, Cooper, Sox, Chan, Fireman, Cheetham, Ray, Selby.
Acquisition of data: Habel, Cooper, Sox, Chan, Cheetham, Quinn, Dublin, Boudreau, Andrade, Pawloski, Raebel, Smith, Uratsu, Selby.
Analysis and interpretation of data: Habel, Cooper, Sox, Chan, Fireman, Arbogast, Cheetham, Quinn, Achacoso, Uratsu, Go, Sidney, Nguyen-Huynh, Ray, Selby.
Drafting of the manuscript: Habel.
Critical revision of the manuscript for important intellectual content: Cooper, Sox, Chan, Fireman, Arbogast, Cheetham, Quinn, Dublin, Boudreau, Andrade, Pawloski, Raebel, Smith, Achacoso, Uratsu, Go, Sidney, Nguyen-Huynh, Ray, Selby.
Statistical analysis: Cooper, Fireman, Arbogast, Achacoso, Uratsu.
Obtained funding: Habel, Cooper, Chan, Quinn, Selby.
Administrative, technical, or material support: Chan, Quinn, Andrade, Achacoso, Uratsu, Selby.
Study supervision: Habel, Cooper, Sox, Chan, Quinn, Andrade, Smith.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Habel reported receiving grants from Merck for a study of herpes zoster in patients with cancer, from Takeda for a study of pioglitazone and cancer, and from sanofi-aventis for a study of insulin and cancer. Dr Chan reported receiving support for travel to meetings for the purpose of the study or other purposes from the US Food and Drug Administration (FDA) and that he is a part-time employee of OptumInsight, a for-profit company that receives funding from medical product manufacturers to provide consultation and conduct research on medical products; because OptumInsight is a part of UnitedHealthGroup, Dr Chan has received UnitedHealthGroup stock options. Dr Dublin reported receiving a Merck/American Geriatrics Society New Investigator Award (honorarium paid directly to Dr Dublin) for unrelated work. Dr Andrade reported that the Meyers Primary Care Institute has received funding from GlaxoSmithKline and Novartis Pharmaceuticals, manufacturers of medications used to treat ADHD. Dr Smith reported that the Center for Health Research received funding from Abbott Laboratories to conduct a natural history study of patients with chronic kidney disease and from GlaxoSmithKline to study the burden of diabetes. Dr Sidney reported receiving grants or grants pending from the National Heart, Lung, and Blood Institute, the National Institute of Neurological Disorders and Stroke, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Thrasher Research Fund. Dr Nguyen-Huynh reported receiving grants or grants pending from the American Heart Association. No other authors reported disclosures.
Funding/Support: This project was funded in part under contract numbers HHSA290-2005-0042 (Vanderbilt) and HHSA290-2005-0033 (Harvard Pilgrim Health Care Institute) from the Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services, as part of the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) program. The project was also funded by the FDA under contracts 223-2005-10012 (Kaiser Permanente Northern California), 223-2005-10100C (Vanderbilt), 223-2005-20006C (Ingenix), and 223-2005-10012C (Harvard Pilgrim Health Care Institute). The project was also funded by the National Institute on Aging under contract K23AG028954 (Group Health Research Institute).
Role of the Sponsors: Individuals from the AHRQ and FDA were on the study Steering Committee and provided input into the study design and conduct of the study and interpretation of the data. The AHRQ and FDA had no role in the preparation, review, or approval of the manuscript.
Disclaimer: The authors of this article are responsible for its content. Statements in the article should not be construed as endorsement by the AHRQ or the US Department of Health and Human Services.
Online-Only Material: The Author Video Interview is available here.
Additional Contributions: We acknowledge and thank the following individuals for their contributions to this project: Andrew Mosholder, MD (FDA), member of Scientific Steering Committee; James Daugherty, MS, and Judith Dudley, BS (Vanderbilt University School of Medicine), programming; Chantal Avila, MA (Kaiser Permanente Southern California), project management; Yan Luo, PhD, and Wansu Chen, MS (Kaiser Permanente Southern California), programming; Mary Kershner, BSN (Kaiser Permanente Colorado), chart reviews and abstraction; April Duddy, MS (Harvard Pilgrim Health Care Institute), project management; Luana Acton, BS, Julie Munneke, BA, and Heidi Krause, BA (Kaiser Permanente Northern California), project management; and Jean Lee, BA, and Monica Highbaugh, AA (Kaiser Permanente Northern California), medical record retrieval and abstraction. All individuals acknowledged were compensated for their time.