Author Contributions: Dr Kostis had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Kostis, Pressel, Davis.
Acquisition of data: Kostis, Cosgrove, Deng, Pressel, Davis.
Analysis and interpretation of data: Kostis, Cabrera, Cheng, Cosgrove, Davis.
Drafting of the manuscript: Kostis, Cosgrove.
Critical revision of the manuscript for important intellectual content: Kostis, Cheng, Deng, Pressel, Davis.
Statistical analysis: Cabrera, Cheng, Davis.
Obtained funding: Kostis, Pressel.
Administrative, technical, or material support: Kostis, Cosgrove, Deng, Pressel.
Study supervision: Kostis, Cabrera, Cosgrove.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kostis reported receiving grant support and travel to meetings from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Aging (NIA). Dr Cabrera reported receiving consulting fees or honorarium from UMDNJ. Ms Cosgrove reported receiving support for travel to meetings from the NHLBI and the NIA. Ms Pressel reported receiving grant support and travel to meetings from the NHLBI and the NIA. Dr Davis reported receiving grant support and travel to meetings from the NHLBI and the NIA, and being a board member of data monitoring committees of Amgen and Merck. Drs Cheng and Deng reported no disclosures.
Funding/Support: This work was supported in part by a grant from the National Heart, Lung, and Blood Institute, the National Institute on Aging, and the Robert Wood Johnson Foundation (Drs Kostis and Davis and Ms Pressel).
Role of the Sponsors: The National Heart, Lung, and Blood Institute and the National Institute on Aging participated in the design, conduct, and reporting of the clinical trial but not in the long-term study reported herein. The Robert Wood Johnson Foundation had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: Jeanne Dobrzynski, BA (employee of UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey), provided technical and editorial assistance. Ms Dobrzynski did not receive any additional compensation for her contribution.