Causes of Death Among Stillbirths FREE

Stillbirth, defined as fetal death at 20 weeks' gestation or later, is one of the most common adverse pregnancy outcomes in the United States and affects approximately 1 in 160 pregnancies.¹ These approximately 26 000 stillbirths per year are equivalent to the number of infant deaths.² The stillbirth rate in the United States is higher than that of many other developed countries.^3- 5 From 1990-2003, the stillbirth rate declined slowly but steadily, by an average of 1.4% per year. In contrast, the infant mortality rate declined twice as fast by an average of 2.8% per year.¹ Since 2003 the stillbirth rate in the United States has remained stagnant at 6.2 stillbirths per 1000 births,¹ 59% higher than the Healthy People 2010 target goal of 4.1 fetal deaths per 1000 births.⁶

US stillbirth prevalence shows significant racial disparity. The stillbirth rate for non-Hispanic black women is 2.3-fold higher than that of non-Hispanic white women (11.13 compared with 4.79 fetal deaths per 1000 live births and fetal deaths).¹ The rate for Hispanic women is 14% higher than for non-Hispanic white women (5.44 per 1000 live births and fetal deaths). Much of the racial disparity in stillbirth remains unexplained.^7- 11

The Stillbirth Collaborative Research Network (SCRN) was initiated by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to address this major public health issue. A workshop of experts convened by NICHD in 2001 concluded that vital records were inadequate to address the scope and causes of stillbirth.¹² Therefore, one of the main objectives of SCRN was to ascertain the causes of stillbirth in a racially and geographically diverse population in the United States. To address this and other objectives, SCRN designed and conducted a multicenter population-based case-control study of stillbirths and live births enrolled at delivery. This article reports the causes of death among the stillbirths according to gestational age at delivery and race/ethnicity.

Between March 2006 and September 2008, SCRN conducted a prospective population-based, case-control study of stillbirth, with enrollment of stillbirths and live births at the time of delivery. The study design and methods have been described in detail.¹³ This study only includes the cohort of stillbirths.

SCRN catchment areas were defined by state and county boundaries and included portions of 5 states: Rhode Island, Massachusetts, Georgia, Texas, and Utah. The study was conducted through 59 tertiary care and community hospitals that covered at least 90% of the stillbirth and live birth deliveries to residents in the catchment areas. Together, these hospitals had more than 80 000 deliveries per year.¹³ Women eligible to participate were residents of an SCRN catchment area who delivered at one of the study hospitals. A stillborn fetus was defined by Apgar scores of 0 at 1 and 5 minutes and no signs of life by direct observation. Deliveries resulting from the termination of a live fetus were excluded.

Gestational age was determined by the best clinical estimate using multiple sources including assisted reproductive technology with documentation of the day of ovulation or embryo transfer, first day of the last menstrual period, and obstetric sonograms.¹⁴ Although stillbirth was defined as death at 20 weeks' gestation or later, fetal deaths between 18 weeks (plus 0 days) through 19 weeks (plus 6 days) gestation and without good dating criteria also were included to avoid missing additional fetal deaths that may have been greater than 20 weeks' gestation.¹³

This study was approved by the institutional review boards of each clinical site, the 59 participating hospitals, and the data coordinating center. An advisory board reviewed the progress and safety of the study. All participants provided written informed consent. The institutional review board approved tracking of limited deidentified demographic data from women who declined participation.

Study components included a comprehensive standardized fetal postmortem examination and uniform placental pathology evaluation performed by a perinatal pathologist.^15- 16 A standardized maternal interview during the delivery hospitalization and detailed chart abstractions of prenatal office visits, antepartum hospitalizations, and the delivery hospitalization were performed. Maternal race/ethnicity was assessed to address racial disparity in stillbirth. Race/ethnicity was self-reported in response to options provided by the investigators. Collected biospecimens included maternal blood for serum and DNA, fetal blood from the umbilical cord (when available), placental tissue, and fetal tissue.

For stillbirths, a set of laboratory studies was recommended to clinicians practicing in all of the participating hospitals. These tests are part of the clinically recommended evaluation for stillbirth.¹⁷ Perinatal postmortem examination, placental histopathology, fetal karyotype, testing for fetal-maternal hemorrhage, antibody screen, serologic test for syphilis, parvovirus serology, glycated hemoglobin, anticardiolipin antibodies, and toxicology screen were included. Studies were intended to screen for conditions known to be associated with stillbirth such as infections, chromosomal and fetal structural abnormalities, maternal-fetal hemorrhage, and maternal disease.

When possible, research samples were used to perform clinically indicated tests that were not obtained at the time of delivery. These included antibody screen, serologic test for syphilis, parvovirus serology, fructosamine (as a marker for hyperglycemia), and anticardiolipin antibodies.

SCRN investigators developed the initial causes of fetal death (INCODE) research tool to systematically assign causes of death using a priori definitions based on the best available evidence.¹⁸ A condition was considered to be a probable cause of stillbirth if it had a high likelihood of directly causing the fetal death; if a condition was not a direct cause of the stillbirth, but possibly involved in a pathophysiologic sequence that led to the fetal death, it was considered a possible cause of death; and potentially important conditions that were present but did not meet criteria for probable or possible causes of death were recorded as present. Thus, INCODE acknowledges the uncertainty as to a specific cause of stillbirth from many potential causes. As an example, diabetes was considered a probable cause if the fetus had diabetic embryopathy with lethal anomalies or the mother had diabetic ketoacidosis; a possible cause if the mother had poor glycemic control documented and the fetus had abnormal growth; and condition present if the mother had good control or the fetus had no other abnormalities.¹⁸ In cases in which criteria were met for more than 1 cause of death, all were recorded without choosing a single cause as primary cause of death. The tool has content validity because it originated from a review of the published research to date and the agreement of the experts who comprised the network. INCODE is intended for use in cases of stillbirth with extensive evaluation including postmortem examination and placental histology. It also is intended as an evolving tool with plans to modify it as data from our study are analyzed.

Each case of stillbirth was reviewed centrally and in detail by 2 physicians (maternal-fetal medicine or neonatology specialties). Difficult cases were evaluated and adjudicated by a multidisciplinary panel with expertise in genetics and perinatal pathology.

Causes of death were grouped into broad categories for purposes of analysis: placental conditions; obstetric complications such as cervical insufficiency, placental abruption, preterm labor, and preterm premature rupture of membranes; fetal major structural malformations and/or genetic abnormalities; infections involving the fetus, placenta, or severe maternal systemic infection; maternal medical conditions including diabetes and antiphospholipid syndrome; hypertensive disorders (chronic hypertension and preeclampsia); umbilical cord abnormalities such as prolapse, strictures, and thrombosis; and other conditions such as hydrops and early amnion rupture sequence.

Descriptive statistics were used to characterize the stillbirths on a range of demographic features and obstetrical and delivery services, with each stillbirth treated as an independent observation in a population consisting of the 5 catchment areas. Fisher exact and χ² tests were used to assess associations. For P values less than .05 with multiple degrees of freedom, further consideration was given to 1 degree of freedom contrasts of interest. Cochran-Mantel-Haenszel methods (modified ridit scoring) were used to test for differences in trends and correlations. All P values were nominal and are provided for descriptive purposes. Point estimates and confidence intervals are given for contrasts of interest. Latent class analysis was used to identify cases that were similar to one another with respect to gestational age, timing of death (antepartum/intrapartum), and causes of death in a multivariable approach. Identified clusters may reflect an unmeasured (latent) grouping that might not otherwise be recognized. Models with 2 to 5 classes or clusters were estimated and the most appropriate model was selected based on model fit indices (Akaike, Bayesian, and sample-adjusted Bayesian information criterion measures) and the interpretability of the classes. The generalized estimating equations technique was used to compute robust variance estimates to account for dependencies due to multiple stillbirths within pregnancies. These estimates were used to confirm conclusions based on methods that treated the stillbirths as independent observations. Generalized estimating equations models were also used to evaluate associations with causes of stillbirth adjusted for differences by clinical site. SAS/STAT software version 9.2 of the SAS System for Windows was used for data analysis except for the latent class analysis, which was conducted using the MPLus software program.¹⁹

There were 953 eligible women with stillbirths (972 stillbirths) within the catchment areas over the surveillance period (Figure). Of these, 126 (13.2%) were not approached, either because they were not identified before discharge from the hospital or because the family or caregiver requested privacy. An additional 164 (17.2%) were approached but refused participation, leaving 663 (69.6%) women enrolled (676 stillbirths). Women who did not enroll in the study (n = 290) did not differ from those enrolled according to maternal age, maternal race/ethnicity, insurance/method of payment, and gestational age at delivery (Table 1). Of the 663 women enrolled, 560 (84.0%) consented to a partial or complete postmortem examination. This report focuses on the 500 women (75.4%) who consented to their 512 stillborn neonates undergoing a complete postmortem examination. Of these 512 stillbirths, 425 (83.0%) occurred prior to the onset of labor and were considered antepartum stillbirths. Among stillbirth pregnancies, 465 were singleton, 34 were twin (22 with 1 stillbirth and 12 with 2 stillbirths), and 1 was triplet (with 1 stillbirth and 2 live births). Women with stillbirth who enrolled in the study and did or did not have a complete postmortem examination had similar age, race/ethnicity, marital status, insurance status, and income (Table 1). Those with a complete postmortem examination were slightly more likely to have received first- or second-trimester prenatal care (93.8% [469] vs 89.0% [145]; difference, 4.8%; 95% CI, 0.0%-10.1%; P = .04), and have a college education, (50.4% [238] vs 37.1% [52]; difference, 13.3%; 95% CI, 4.1%-22.5%; P = .01) than those declining complete postmortem examination.

Participants in this study comprised 180 (36.1%) non-Hispanic white, 171 (34.3%) Hispanic, 112 (22.4%) non-Hispanic black, and 36 (7.2%) women of other race/ethnicities. Their mean age was 27.4 years (range, 14-45 years), 238 (50.2%) were married, 469 (93.8%) had first or second trimester prenatal care, 211 (42.5%) had veterans' benefits or private insurance, 255 (51.3%) received public assistance, and 31 (6.2%) were uninsured.

Almost one-third of stillbirths—160 (31.3%)—occurred between 20 and 24 weeks' gestation and 259 (50.6%) occurred prior to 28 weeks' gestation (Table 2). The gestational age of antepartum and intrapartum stillbirths differed significantly (P < .001) with 73 (83.9%) intrapartum stillbirths occurring at less than 24 weeks gestation vs antepartum stillbirths being relatively evenly distributed over all gestational ages.

Non-Hispanic black women had a higher percentage of intrapartum stillbirths (33.0% [38] vs 9.3% [17] when compared with non-Hispanic white women; difference, 23.7%; 95% CI, 14.2%-33.3%; P < .001), and Hispanic women (14.8% [26]; difference, 18.2%; 95% CI, 8.2%-28.3%; P < .001). Stillbirths in non-Hispanic black women occurred earlier in gestation than those occurring in women of other race /ethnicities (P = .001 for differences in gestational age by race/ethnicity).

A probable cause of death was found in 312 of the stillbirths (60.9%; 95% CI, 56.5%-65.2%) and a possible or probable cause in 390 cases (76.2%; 95% CI, 72.2%-79.8%). More than 1 probable or possible cause of death was found in 161 stillbirths (31.4%; 95% CI, 27.5%-35.7%). The distribution of causes of death (probable and possible) within broad categories, stratified by relation to labor and gestational age, are shown in Table 3 and eTable 1). Obstetric complications were the most common category for cause of death (150 cases [29.3%; 95% CI, 25.4%-33.5%]), including abruption (38 cases [7.4%; 95% CI, 5.4%-10.1%]), complications of multiple gestation (31 cases [6.1%; 95% CI, 4.2%- 8.6%]), and the constellation of preterm labor, preterm premature rupture of membranes, and cervical insufficiency, often in combination with chorioamnionitis (77 cases [15.0%; 95% CI, 12.1%-18.5%]). Placental abnormalities were implicated in 121 cases (23.6%; 95% CI, 20.1%-27.6%) including 24 with clinical evidence of uteroplacental insufficiency (4.7%; 95% CI, 3.1%-7.0%) and 39 with maternal vascular disorders (7.6%; 95% CI, 5.5%-10.4%). Other causes included fetal genetic/structural abnormalities in 70 cases (13.7%; 95% CI, 10.9%-17.0%), infection in 66 (12.9%; 95% CI, 10.2%-16.2%), umbilical cord abnormalities in 53 (10.4%; 95% CI, 7.9%-13.4%), hypertensive disorders in 47 (9.2%; 95% CI, 6.9%-12.1%), and maternal medical complications in 40 (7.8%; 95% CI, 5.7%-10.6%).

The distributions of causes of death differed between antepartum and intrapartum stillbirths. All intrapartum stillbirths were classified as obstetric complications. A higher percentage of intrapartum stillbirths had infectious causes (26.4% [23] vs 10.1% [43] compared with antepartum stillbirths; difference, 16.3%; 95% CI, 6.6%-26.0%; P < .001). Antepartum stillbirths, when compared with intrapartum stillbirths, had a higher proportion of placental causes (26.1% [111] vs 11.5% [10]; difference, 14.6%; 95% CI, 6.7%-22.5%; P = .003) and fetal genetic/structural abnormalities (15.5% [66] vs 4.6% [4]; difference, 10.9%; 95% CI, 5.3%-16.5%; P = .007).

Placental disorders were associated with a higher proportion of stillbirths after 24 weeks' gestation (28.4% [97] vs 14.1% [24]; difference, 14.3%; 95% CI, 7.2%-21.3%; P < .001). By contrast, stillbirths at less than 24 weeks' gestation had a much higher proportion of obstetric complications (52.4% [89] vs 17.8% [61]; difference, 34.6%; 95% CI, 26.0%-43.1%; P < .001) and infections (21.8% [37] vs 8.5% [29]; difference, 13.3%; 95% CI, 6.4%-20.2%; P < .001).

Table 4 shows the probable and possible causes of death stratified by race/ethnicity. Non-Hispanic black women experienced a higher proportion of stillbirths associated with obstetric complications compared with non-Hispanic white women and Hispanic women combined (43.5% [50] vs 23.7% [85]; difference, 19.8%; 95% CI, 9.7%-29.9%; P < .001), and infections (25.2% [29] vs 7.8% [28]; difference, 17.4%; 95% CI, 9.0%-25.8%; P < .001). Conversely, cord abnormalities were associated with a higher proportion of stillbirths in non-Hispanic white and Hispanic women compared with non-Hispanic black and other women (12.8% [46] vs 4.6% [7]; difference, 8.2%; 95% CI, 3.4%-13.0%; P = .005). Categories of probable and possible causes of death did not differ by race/ethnicity in the subset of stillbirths that were antepartum or the subset that occurred after 24 weeks' gestation.

After using generalized estimating equations to account for dependencies between twin stillbirths and adjusting for clinical site, differences in the causes of stillbirth remained significant (eTable 2). Cluster analysis was conducted to look for natural groupings of the cases according to gestational age, timing in relation to labor, and causes of death (Table 5). The 4-class solution was selected based on model fit indices and interpretability. A 2-class solution separated early from late gestational age at death; whereas a 3-class solution distinguished early, mid, and late gestation. The 4-class solution further split early gestations into 2 clusters. Class 1 contained 76 of the cases (14.8%; 95% CI, 11.9%-18.3%) including all intrapartum cases and those with gestational ages of less than 28 weeks. The most common causes of death were obstetric complications (100%) and infection (20 [26.3%]; 95% CI, 17.2%-37.9%) in class 1. Thirty-six of the stillbirths in class 1 were born to non-Hispanic black women (47.4%; 95% CI, 35.9%-59.1%). Class 2 contained 138 of the stillbirths (27.0%; 95% CI, 23.2%-31.1%), all of which occurred at less than 28 weeks' gestation and all but 1 were antepartum. Ninety-seven occurred at less than 24 weeks' gestation (70.3%; 95% CI, 61.8%-77.6%). The most common causes of death were placental disease (32 [23.2%; 95% CI, 16.6%-31.3%]), fetal genetic/structural abnormalities (24 [17.4%; 95% CI, 11.7%-25.0%]), and obstetric complications (24 [17.4%; 95% CI, 11.7%-25.0%]). Class 3 included 126 of the stillbirths (24.6%; 95% CI, 21.0%-28.6%) and ranged between 24 and 36 weeks' gestation with 72 (57.1%; 95% CI, 48.0%-65.8%) occurring at 28 to 31 weeks. Placental disease (43 [34.1%; 95% CI, 26.1%-43.2%]) and hypertensive disorders (27 [21.4%; 95% CI, 14.8%-29.8%]) were more common in class 3. Class 4 stillbirths (n=172) occurred later in gestation (≥32 weeks) and were 33.6% (95% CI, 29.5%-37.9%) of stillbirths. There were more cord abnormalities in class 4 (25 [14.5%; 95% CI, 9.8%-20.9%]) than the other classes. Classes 2, 3, and 4 had similar race/ethnicity distributions.

The proportions of positive results for clinically indicated tests are shown in Table 6. Placental histology had the highest proportion of positive results (52.3% [268]; 95% CI, 47.9%-56.7%), defined as abnormalities contributing to a probable or possible cause of death. Perinatal postmortem examination had positive findings in 161 cases (31.4%; 95% CI, 27.5%-35.7%) and karyotype was abnormal in 32 of the 357 successful studies (9.0%; 95% CI, 6.3%-12.5%). Three hundred forty cases (66.4%; 95% CI, 62.1%-70.5%) had a positive result for at least 1 of these 3 tests. The remaining clinically indicated tests were positive in only 0.4% to 4.8% of stillbirths.

In this large US population-based cohort of stillbirths, systematic and thorough evaluation led to the ascertainment of a probable or possible cause of death in the vast majority of cases. Using INCODE, a rigorous classification tool developed from published evidence,¹⁸ a probable cause of death was found in 61% of cases and a possible or probable cause was found in more than 76% of cases. These causes were differentially distributed across gestation and racial/ethnic groups, which has implications for monitoring and prevention.

The lack of information on causes of stillbirth has made it difficult to provide answers to families as well as design strategies for prevention. In the United States, evaluations for causes of stillbirth are often incomplete,^20- 21 eg, the rate of perinatal postmortem examination is estimated at less than 50% in all but a few dedicated centers.²² Reasons for failure to perform fetal autopsy include clinicians' lack of knowledge, physician and patient discomfort with death and discussion of postmortem examination, concerns about cost, and limited availability of services.

Our data support performing perinatal postmortem examination, placental histology, and karyotype in all cases of stillbirth because the majority of stillbirths (66%) had at least 1 positive result out of these 3 components of the evaluation. Although other diagnostic tests have a lower yield, their utility should be considered in specific clinical scenarios according to cost and availability.

Placental disease was the leading cause of antepartum stillbirths (26%). This proportion was similar to that observed in a cohort of stillbirths in Sweden (23%).²³ However, in a Dutch cohort of 750 antepartum stillbirths, 65% were attributed to placental abnormalities.²⁴ Placental disease has been recently recognized as an important contributor in antepartum stillbirths and those that would have been considered unexplained; however, the proportion of cases attributed to placental anomalies varies depending on the criteria used. Without clinical evidence of placental insufficiency (eg, fetal growth impairment, oligohydramnios, preeclampsia), it is difficult to determine whether specific placental abnormalities are associated with stillbirth since similar abnormalities are sometimes present in the placentas of normal pregnancies.

The proportion of SCRN cases attributed to infectious causes was similar to other recent studies in which 14% to 19% of stillbirths were because of infection.^23- 26 The proportion of stillbirths from chromosomal abnormalities also was similar to other studies.^23,27 A higher proportion of cases in our study were associated with obstetric abnormalities than previously reported in other studies. In part, this observation is likely due to the inclusion of intrapartum cases as well as the racial/ethnic diversity in our cohort. In addition, obstetric conditions have not been systematically evaluated in a large, population-based cohort in the United States.

Umbilical cord abnormalities accounted for 10% of our possible or probable causes of death, which is considerably higher than in previous studies,^23- 24 and were more common in stillbirths of greater than 32 weeks' gestation. Nuchal cords are noted in almost one-fourth of uncomplicated pregnancies.²⁸ Our criteria for considering a cord abnormality to be a cause of death were rigorous and included vasa previa, cord entrapment, and evidence of occlusion and fetal hypoxia, prolapse, or stricture with thrombi.^18,29 Nuchal cord alone was not considered a cause of death. This important cause of stillbirth has been somewhat overlooked in prior studies because of the difficulty in differentiating between harmless nuchal cords and cord conditions associated with pathophysiology leading to stillbirth. As a potentially preventable cause of stillbirth, cord abnormalities deserve further investigation.

The consistent and persistent racial disparity in stillbirth (2.3-fold risk for non-Hispanic black compared with non-Hispanic white women in the United States in 2005)¹ remains largely unexplained.^7- 11 This disparity is often attributed to poor access to prenatal care.⁷ However, racial disparity for stillbirth persists, even in women with prenatal care.⁹ This is the first US study with large, diverse, well-defined catchment areas describing the causes of stillbirth by race/ethnicity. Our findings strongly suggest that a majority of the excess rate of stillbirth in non-Hispanic black women is due to obstetric complications, infection, or both causes combined with stillbirth often occurring intrapartum and at less than 24 weeks' gestation. The pathophysiology of these conditions is similar if not identical to the pathophysiology of spontaneous preterm birth, a condition with well-documented racial disparity. Non-Hispanic black women had a rate of spontaneous preterm birth of 18.3% compared with 11.5% for non-Hispanic white women in the United States in 2007.³⁰ When conditions such as preterm labor, cervical insufficiency, preterm premature rupture of membranes, chorioamnionitis, and abruption lead to labor at a previable or periviable gestation, antepartum or intrapartum death is usually allowed to occur without obstetric intervention. If the same condition occurs at a viable gestation (eg, after 24 weeks' gestation), cesarean delivery may lead to preterm birth rather than stillbirth. This observation allows us to target strategies intended to reduce the racial disparity in stillbirths. For example, measures that successfully reduce the rate of spontaneous preterm birth in non-Hispanic black women (such as treatment with progestational agents) could potentially reduce the rate of stillbirth as well.

The latent class analysis provides a new perspective to the heterogeneous nature of stillbirths. There are 4 distinct categories of stillbirths based on gestational age, race/ethnicity, and causes of death. This multivariable statistical technique has allowed us to recognize that there are 2 classes of early stillbirths (<28 weeks' gestation) with different etiologies and racial composition. Class 1 includes intrapartum deaths, which are more common among non-Hispanic black women, and class 2, which includes antepartum deaths, which are more diverse in origin with only 17% attributed to obstetrical causes and almost one-fourth associated with placental disease. Fifty-seven percent of stillbirths with hypertensive disease designated as a cause were in class 3, which occurred primarily between weeks 24 and 31, while almost half of the deaths due to cord abnormalities occurred at later gestations (class 4). Placental disease was evenly distributed across gestation for antepartum stillbirths, possibly reflecting multiple mechanisms leading to stillbirth. This knowledge of the timing and duration of these conditions in relation to stillbirth is helpful in the development of new preventive strategies.

Our study had several limitations. A potential source of bias was that 30% of women experiencing stillbirth in our catchments were not enrolled. The study was conducted in 59 hospitals and many patients with stillbirth were hospitalized for only a short duration, often less than 24 hours. Despite intensive surveillance, on occasion study personnel were not notified of cases. Also, because stillbirth is an emotional event, some families were distraught and did not wish to participate in a research study at that time. Additionally, the caregiver could decide that the family should not be approached due to the circumstances. Importantly for our study, demographic characteristics were similar among women who did and did not enroll. The cases in this report were confined to the subset that underwent postmortem examination, another possible source of bias. Women who consented to autopsy were slightly more likely to have received early prenatal care and a larger percentage had a college education. Also, some of the stillbirths did not undergo some of the clinically indicated tests and documentation of conditions in prenatal and hospital records had differing levels of detail, which could have introduced bias in ascertaining cause. Some differences were noted in the identified causes of stillbirth by clinical site. Although these differences cannot be completely disentangled from patient characteristics in analysis, the differences in causes of stillbirth by race/ethnicity remained significant after adjustment for clinical site. Finally, the sample size was not large enough to ascertain rare causes of stillbirth.

There were numerous strengths of the study. Each patient had an extensive standardized evaluation for potential causes of stillbirth including postmortem examination, placental histology, karyotype, maternal interview, and abstraction of medical records. This allowed for a level of detail and accuracy that is not available from large databases, especially those using vital statistics. Indeed, information contained in fetal death certificates in the United States is often incomplete or inaccurate.²⁰ Our systematic approach to the evaluation of each case, which included a classification tool with rigorous criteria, an extensive review by 2 medical experts, and an adjudication process, was also a strength.

The study was population based and geographically, racially, and ethnically diverse, making the results more generalizable. The study was designed to have access to at least 90% of all deliveries in each catchment area, and almost all hospitals within each catchment area participated, including a large proportion of community hospitals. The proportion of non-Hispanic black women in our stillbirth cohort was similar to the proportion reported in US vital statistics (22.4% vs 25.4%) and the proportion Hispanic was greater (34.3% vs 20.8%). This enabled us to examine disparities by race/ethnicity in causes of death.¹

The US stillbirth rate has remained unacceptably high, affecting 1 in 160 pregnancies each year. Reduction in the stillbirth rate will require thorough investigation into the cause of death. After a systematic and thorough evaluation, a cause of death was determined in the majority of cases of stillbirth in our study. Therefore, postmortem examination, placental histology, and karyotype are strongly recommended as part of the diagnostic evaluation. In addition, the development of interventions to prevent stillbirth should consider the observed differential distribution of causes of death as gestational age advances, as well as variation by race/ethnicity.