Author Contributions: Dr Canto had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Canto, Peterson, French, Pollack.
Acquisition of data: Canto, Peterson, French, Pollack.
Analysis and interpretation of data: Canto, Kiefe, Rogers, Peterson, Frederick, French, Gibson, Pollack, Ornato, Zalenski, Penney, Tiefenbrunn, Greenland.
Drafting of the manuscript: Canto, Peterson, French, Ornato.
Critical revision of the manuscript for important intellectual content: Canto, Kiefe, Rogers, Peterson, Frederick, French, Gibson, Pollack, Ornato, Zalenski, Penney, Tiefenbrunn, Greenland.
Statistical analysis: Canto, Peterson, Frederick, Penney.
Obtained funding: Peterson.
Administrative, technical, or material support: Penney.
Study supervision: Canto, French.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kiefe reports receiving partial funding from the National Institutes of Health (grants U01HL 105268 and U54 RR 026088). Dr Peterson reports receiving grants from Bristol-Myers Squibb/sanofi, Eli Lilly, and Johnson & Johnson. Mr Frederick reports being an employee of ICON Clinical Research, which received support from Genentech Inc to provide biostatistical and analytic services. Dr Gibson reports that his institution received a grant from Genentech for a research trial. Dr Pollack reports serving as a consultant and on the speakers bureau for sanofi-aventis. Dr Ornato reports being an unpaid advisory board member for ZOLL. No other disclosures were reported.
Funding/Support: The National Registry of Myocardial Infarction was supported by Genentech Inc.
Role of the Sponsor: The study sponsor approved the final manuscript but did not participate in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation of the manuscript.
Disclaimer: Dr Peterson, a contributing editor for JAMA, was not involved in the editorial review of or decision to publish this article.