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Commentary | November 2, 2011

Detours on the Road to Personalized Medicine: Barriers to Biomarker Validation and Implementation

Louis D. Fiore, MD, MPH; Leonard William D’Avolio, PhD

JAMA. 2011;306(17):1914-1915. doi:10.1001/jama.2011.1605.

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The sequencing of the human genome, the ability to perform genome-wide association studies, and the development of high-throughput nucleotide sequencing support the goals of personalized medicine. “Next generation” sequencing platforms now provide much higher resolution of DNA than was possible with microarray-based–single nucleotide polymorphism (SNP) detection. Other breakthrough technologies such as the ability to sequence DNA from single cells, targeted mRNA molecules, and methylated regions of DNA; DNA fragment length analysis; isolation of circulating tumor cells; and the ability to use paraffin-embedded tissue for mRNA sequencing will make genotyping faster, easier, less expensive, better, and ultimately more readily available.

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Fiore LD, D’Avolio L. Detours on the Road to Personalized Medicine: Barriers to Biomarker Validation and Implementation. JAMA. 2011;306(17):1914-1915. doi:10.1001/jama.2011.1605.

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