Published Online: October 5, 2011. doi:10.1001/jama.2011.1435
Author Contributions: Dr Thompson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Rice, Wheeler, Thompson, deBoisblanc, Steingrub, Rock.
Acquisition of data: Rice, Wheeler, Thompson, deBoisblanc, Steingrub, Rock.
Analysis and interpretation of data: Rice, Wheeler, Thompson, Steingrub, Rock.
Drafting of the manuscript: Rice, Wheeler, Thompson, Steingrub, Rock.
Critical revision of the manuscript for important intellectual content: Rice, Wheeler, Thompson, deBoisblanc, Steingrub, Rock.
Statistical analysis: Thompson.
Obtained funding: deBoisblanc, Steingrub.
Administrative, technical, or material support: Rice, Wheeler, Thompson, deBoisblanc, Steingrub, Rock.
Study supervision: Rice, Wheeler, Thompson, deBoisblanc, Rock.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was supported by National Heart, Lung, and Blood Institute (NHLBI) contracts HHSN268200536165C, HHSN268200536176C, and HHSN268200536179C. Abbott Nutrition, Columbus, Ohio, provided the omega-3 fatty acid, γ-linolenic acid, antioxidant, and control supplements used in the study.
Role of the Sponsor: Neither the NHLBI nor Abbott Nutrition had any role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators: University of Washington, Harborview (*L. Hudson, C. Hough, M. Neff, K. Sims, T. Watkins); Baystate Medical Center (*J. Steingrub, *M. Tidswell, L. DeSouza, C. Kardos, L. Kozikowski, K. Kozikowski); Baylor College of Medicine (K. Guntupalli, V. Bandi, C. Pope); Johns Hopkins Hospital (*R. Brower, H. Fessler, D. Hager, P. Mendez-Tellez, K. Oakjones, D. Needham); Johns Hopkins Bayview Medical Center (J. Sevransky, A. Workneh, S. Han, S. Murray); University of Maryland (C. Shanholtz, G. Netzer, P. Rock, A. Sampaio, J. Titus); Union Memorial Hospital (P. Sloane, T. Beck, H. Highfield); Washington Hospital Center (D. Herr, B. Lee, N. Bolouri); Cleveland Clinic Foundation (*H.P. Wiedemann, R.W. Ashton, D.A. Culver, T. Frederick, J.J. Komara, J.A. Guzman, A.J. Reddy); University Hospitals of Cleveland (R. Hejal, M. Andrews, D. Haney); MetroHealth Medical Center (A.F. Connors, S. Lasalvia, J.D. Thornton, E.L. Warren); University of Colorado Health Science Centers (*M. Moss, A. Benson, E. Burnham, B. Clark, L. Gray, C. Higgins, B.J. Maloney, M. Mealer); National Jewish Health (S. Frankel); St Anthony's Hospital (T. Bost, P. Dennen, K. Hodgin); Denver Health Medical Center (I. Douglas, K. Overdier, K. Thompson, R. Wolken); Duke University (*N. MacIntyre, L. Brown, C. Cox, M. Gentile, J. Govert, N. Knudsen); University of North Carolina (S. Carson, L. Chang, J. Lanier); Vanderbilt University (*A.P. Wheeler, G.R. Bernard, M. Hays, S. Mogan, T.W. Rice); Wake Forest University (*R.D. Hite, P.E. Morris, A. Harvey, M. Ragusky, K. Bender); Moses Cone Memorial Hospital (P. Wright, S. Gross, J. McLean, A. Overton); University of Virginia (J. Truwit, K. Enfield, M. Marshall); LDS Hospital (T. Clemmer, R. Tanaka, L. Weaver); Intermountain Medical Center (*A. Morris, A. Ahmed, A. Austin, N. Dean, C. Grissom, A. Fitzpatrick, E. Hirshberg, S. Brown, N. Kumar, R. Miller, J. Orme, S. Pandita, G. Schreiber, L. Struck, F. Thomas, G. Thomsen, D. VanBoerum, T. White, M. Zenger, D. Dienhart, P. Nelson, M. Goddard, J. Krueger, L. Napoli); McKay-Dee Hospital (C. Lawton, J. Baughman, T. Fujii, D. Hanselman, T. Hoffman, B. Kerwin, P. Kim, F. Leung); Utah Valley Regional Medical Center (K. Sundar, W. Alward, E. Campbell, D. Eckley, T. Hill, K. Ludwig, D. Nielsen, M. Pearce); University of California, San Francisco (*M.A. Matthay, C. Calfee, B. Daniel, M. Eisner, O. Garcia, E. Johnson, R. Kallet, K. Kordesch, K. Liu, H. Zhou); University of California, San Francisco, Fresno (M.W. Peterson, J. Blaauw); University of California, Davis (T. Albertson, E. Vlastelin); Mayo Foundation (*R. Hubmayr, D. Brown, O. Gajic, R. Hinds, S. Holets, D.J. Kor, M. Passe); Louisiana State University (*B. deBoisblanc, P. Lauto, C. Romaine, G. Meyaski, J. Hunt, A. Marr); Louisiana State University–Earl K. Long Medical Center, Baton Rouge General Medical Center Mid-City, and Baton Rouge General Medical Center Bluebonnet (S. Brierre, C. LeBlanc); Alton-Ochsner Clinic Foundation (D. Taylor; S. Jain, L. Seoane); Tulane University (F. Simeone, J. Fearon, J. Duchesne). Clinical Coordinating Center : Massachusetts General Hospital and Harvard Medical School (* D. Schoenfeld, M. Aquino, N. Dong, D. Dorer, M. Guha, E. Hammond, N. Lavery, P. Lazar, I. Molina, R. Morse, C. Oldmixon, B. Rawal, N. Ringwood, A. Shui, E. Smoot, B.T. Thompson). National Heart, Lung, and Blood Institute: A. Harabin, S. Bredow, M. Waclawiw, G. Weinmann. Data and Safety Monitoring Board: R. G. Spragg (chair), A. Slutsky, M. Levy, B. Markovitz, E. Petkova, C. Weijer. Protocol Review Committee: J. Sznajder (chair), M. Begg, E. Israel, J. Lewis, S. McClave, P. Parsons. *Principal investigator.
Additional Contributions: We are indebted to the patients who participated in this study and to the intensive care unit personnel, especially nutrition support services and nurses, for supporting this trial.
This article was corrected for errors on October 18, 2011.
This article was corrected for errors on December 8, 2011.