To the Editor: A recent study1 found an inverse association of urinary sodium excretion and subsequent CVD, in contrast to a wide body of evidence showing the opposite.2 The study has several analytic limitations.
First, the posited mechanism by which sodium affects CVD is through blood pressure. The authors, however, controlled for baseline blood pressure, thus removing the intermediate effect of sodium on CVD. A well-known principle of epidemiology is to avoid controlling for factors in the causal pathway. In their analysis of CVD outcomes, the authors included an additional analysis unadjusted for blood pressure, but this still controlled for antihypertensive medication. They inappropriately controlled for baseline blood pressure in analyses of incident hypertension, reversing the crude positive association.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.