Author Contributions: Drs Kane, Mahoney, and Rodeheffer had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Kane, Mahoney, Redfield, Roger, Jacobsen, Rodeheffer.
Acquisition of data: Karon, Mahoney, Roger, Jacobsen, Rodeheffer.
Analysis and interpretation of data: Kane, Karon, Mahoney, Roger, Burnett, Jacobsen, Rodeheffer.
Drafting of the manuscript: Kane, Mahoney, Roger, Rodeheffer.
Critical revision of the manuscript for important intellectual content: Karon, Mahoney, Redfield, Burnett, Jacobsen, Rodeheffer.
Statistical analysis: Kane, Mahoney, Rodeheffer.
Obtained funding: Jacobsen, Rodeheffer.
Administrative, technical, or material support: Burnett, Jacobsen, Rodeheffer.
Study supervision: Rodeheffer.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was supported by National Heart, Lung, and Blood Institute grant R01-55502, grant 1UL1RR024150 from the National Institutes of Health (NIH) National Center for Research Resources, and the Mayo Foundation. The research was supported by NIH HL-R01-55502 (Dr Rodeheffer), NIH AR-36582 (Dr Jacobsen), and NIH HL-63281 (Redfield). The project was supported by NIH/National Center for Research Resources (NCRR) Clinical and Translational Science Awards Grant UL RR024150 and by the Rochester Epidemiology Project, grant R01-AG034676 from the National Institute on Aging, and the Mayo Foundation.
Role of the Sponsor: The study sponsors had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Tammy Burns (Mayo Clinic) and Kasey Muetzel (Mayo Clinic) for invaluable assistance in manuscript preparation. Neither of these individuals received any compensation for their contributions apart from their employment. This article is dedicated to the memory of Kenneth L. Baughman, MD, physician and mentor.