Biomedical science has made amazing life-saving discoveries. The science of “omics” offers hope for further improvements in preventing, prognosticating, and personalizing care. Each year, researchers publish approximately 18 000 active clinical trials,1 yet a gap remains between the development and publication of this new knowledge and better patient outcomes. While clinical translational science awards strive to improve population health, their predominant focus has been on translating basic research findings to humans. Although this Commentary focuses on preventable harm within the health care system, the principles discussed likely apply to optimizing population health using a broader set of public health interventions.
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