Up to 1 million patients in the United States may be taking 2 medications that can lead to unexpected increases in blood glucose levels when used simultaneously. Data mining techniques have revealed that the combination of the antidepressant paroxetine and the cholesterol-lowering medication pravastatin may cause this adverse effect (Tatonetti NP et al. Clin Pharmacol Ther. doi: 10.1038/clpt.2011.83 [published online ahead of print May 25, 2011]).
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Mining the data from a federal database of reports of adverse drug events may help uncover unexpected interactions between drugs.
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