To the Editor: Hereditary pancreatitis is an
uncommon variety of pancreatitis. It generally follows an autosomal dominant
inheritance and is associated with germline mutations in the cationic trypsinogen
(PRSS1) gene.1 Thus,
genetic testing is often recommended when 2 or more family members are diagnosed
with idiopathic pancreatitis. However, the prevalence of trypsinogen mutations
among patients with idiopathic pancreatitis and without a family history remains
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