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Spontaneous and Sporadic Trypsinogen Mutations in Idiopathic Pancreatitis

Peter Simon, MD; F. Ulrich Weiss, PhD; Klaus Peter Zimmer, MD; Steven Rand, PhD; Bernd Brinkmann, MD; Wolfram Domschke, MD; Markus M. Lerch, MD
JAMA. 2002;288(17):2122. doi:10.1001/jama.288.17.2118.
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To the Editor: Hereditary pancreatitis is an uncommon variety of pancreatitis. It generally follows an autosomal dominant inheritance and is associated with germline mutations in the cationic trypsinogen (PRSS1) gene.1 Thus, genetic testing is often recommended when 2 or more family members are diagnosed with idiopathic pancreatitis. However, the prevalence of trypsinogen mutations among patients with idiopathic pancreatitis and without a family history remains unknown.


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