To the Editor: In their look-back investigation,
Dr Kopko and colleagues1 reported that 36%
of patients who received transfusions from a frequent plasma donor had reactions
consistent with transfusion-related acute lung injury (TRALI). They also found
that the donor had an anti-5b, a granulocyte-specific alloantibody, which
has been associated with TRALI in both humans and in animal models.2,3
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