In Reply: Dr Corica and colleagues question
the appropriateness of our speculation about potential therapeutic interventions
targeting elevated leptin in obese patients. Our results and those of others1- 3 indicate that
leptin may promote platelet aggregation by interacting with the leptin receptor
on platelets. Furthermore, a recent clinical study identified plasma leptin
as an independent risk factor for cardiovascular events,4
although mechanisms other than increased platelet aggregation may relate to
this increased risk. Currently, the best treatment for reducing the potential
adverse effects of leptin is probably weight reduction, which is admittedly
difficult. Because of the well-known consequences of leptin deficiency on
weight gain and metabolism,5 we agree that
drug-induced leptin reduction or antagonism might cause more harm than good.
Therefore, targeting the platelet seems to be a more reasonable approach.
However, we certainly agree that there is much to be learned about the mechanism
of leptin-induced platelet aggregation and whether chronically elevated leptin
levels have an effect on thrombosis.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 6
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.