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Loss of HIV-1–Specific Immunity During Treatment Interruption in 2 Chronically Infected Patients

Joel N. Blankson, MD, PhD; Joel E. Gallant, MD, MPH; Thomas C. Quinn, MD; John G. Bartlett, MD; Robert F. Siliciano, MD, PhD
JAMA. 2002;288(2):162-164. doi:10.1001/jama.288.2.162.
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To the Editor: Human immunodeficiency virus 1 (HIV-1) antigen-specific proliferative CD4+ T cell responses are typically absent in patients with chronic HIV-1 infection.1 However, these responses are present in so-called long-term nonprogressors who experience control of viremia even without treatment13 and in patients treated with highly active antiretroviral therapy (HAART) during acute seroconversion who are subsequently able to contain viremia after treatment interruptions.4 These findings suggest that the presence of CD4+ T cell proliferative responses to HIV-1 may be associated with protection against viral replication.

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Figure. Treatment Interruption, Viral Load, and HIV-1 Antigen–Specific CD4 T Cell Proliferative Response in 2 Patients With Chronic HIV Infection
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Break in upper shaded bar indicates time of treatment interruption. HIV indicates human immunodeficiency virus.

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