To the Editor: Flavonoid-rich foods and beverages
have putative vascular health benefits, including protection against ischemic
stroke and reductions in platelet reactivity.1- 5
Tea, grapes, apples, and cocoa contain a class of flavonoids known as the
flavanols, which includes epicatechin and catechin. Flavanols can polymerize,
producing theaflavins and thearubigins (found in tea) and procyanidins (found
in grapes, apples, and cocoa). We previously reported reductions in platelet
primary hemostasis and glycoprotein IIb/IIIa expression 2 and 6 hours after
subjects consumed 300 mL of cocoa containing a total of 897 mg of flavanols
and procyanidins.3 We examined whether smaller
amounts of chocolate could affect platelet function.
ADP indicates adenosine diphosphate.
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Web of Science® Times Cited: 95
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