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Letters | April 10, 2002

Rofecoxib vs Celecoxib vs Acetaminophen for Treatment of Osteoarthritis—Reply

Gregory P. Geba, MD; Adam B. Polis, MA; Arthur L. Weaver, MD; Thomas J. Schnitzer, MD, PhD

JAMA. 2002;287(14):1799-1800. doi:10.1001/jama.287.14.1799.

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In Reply: In response to Dr Bierma-Zeinstra and colleagues, patient compliance was defined as the percent of tablets taken (according to patient report) relative to the number prescribed, an accepted and common method of compliance measurement in clinical trials.¹ Percent compliance for each patient was calculated as the mean percent compliance of the 4 bottles of blinded study medication, irrespective of treatment group to which the patient was assigned. Since more than the number of tablets needed to complete the study were included in each bottle (to ensure sufficient drug in case of accidental losses), if a patient took more tablets than prescribed, the percent compliance would be greater than 100% (this was uncommon). Descriptive statistics for percent compliance for patients randomized to treatment who provided efficacy data are shown in the Table 1.

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Geba GP, Polis AB, Weaver AL, Schnitzer TJ. Rofecoxib vs Celecoxib vs Acetaminophen for Treatment of Osteoarthritis—Reply. JAMA. 2002;287(14):1799-1800. doi:10.1001/jama.287.14.1799.

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