We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Influence of Methodological Quality on Study Conclusions—Reply

Christianne A. van Nieuwenhoven, MD; Frank H. van Tiel, MD, PhD; Erik Buskens, MD, PhD; Marc J. M. Bonten, MD, PhD
JAMA. 2001;286(20):2544-2547. doi:10.1001/jama.286.20.2542.
Text Size: A A A
Published online


In Reply: Dr Liberati and colleagues and Dr Sánchez García point out an error in the "Results" section of our article. The data in Table 2 are based on our initial analyses, which we revised during the review process. We apologize for the confusion. The correct data are presented in Table 1. The chosen cutoff for low- and-high-quality studies is, of course, arbitrary, but the data in Table 1 clearly show that there was no reason for choosing a cutoff point on a post hoc basis. In contrast to the opinion of Liberati et al, we think that SDD studies are very appropriate to explore the relationship between study quality and observed effects. As opposed to mortality, the end point of pneumonia is rather weak since establishing this diagnosis is extremely difficult. Therefore, this end point is prone to investigator bias, which is consistent with our findings. At no point did we claim that only RCTs were included.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.