0
Letters |

Ultrasound Markers of Fetal Down Syndrome

David A. Nyberg, MD
JAMA. 2001;285(22):2856-2858. doi:10.1001/jama.285.22.2856.
Text Size: A A A
Published online

Extract

To the Editor: Dr Smith-Bindman and colleagues 1 have summarized a large amount of potentially useful data but, I believe, have misinterpreted or ignored data that support the use of ultrasonographic markers of Down syndrome. The results of their meta-analysis show that most ultrasonographic markers as isolated findings are statistically associated with an increased risk for fetal Down syndrome (2.8- to 17-fold greater). Furthermore, the combination of anomalies and markers were identified in 69% of fetuses with trisomy 21 (Table 3). This is consistent with other centers reporting detection rates of 59% to 82% 4 when markers are combined with structural anomalies (observed in less than 20% of affected fetuses before 20 weeks at most centers).2,3 Even using outdated assumptions, the authors found a benefit for all markers except choroid plexus cyst among high-risk patients (defined as a relatively low risk of 1 in 300).

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 4

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();