To the Editor: In industrialized countries, chronic pancreatitis (CP) is caused by long-term alcohol abuse in about 70% of cases, whereas the cause is generally unknown in the other 30% of patients. Furthermore, it is unclear how alcohol use may lead to CP, and wide variation exists among individuals in their susceptibility to alcoholic CP (ACP). Only a minority of frequent drinkers develop ACP.1 However, genetic factors may also affect the pathogenesis of ACP.
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