We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Positron Emission Tomography to Evaluate Lung Lesions—Reply

Michael K. Gould, MD, MS; Douglas K. Owens, MD, MS
JAMA. 2001;285(21):2711-2712. doi:10.1001/jama.285.21.2711.
Text Size: A A A
Published online


In Reply: Dr Smith-Bindman notes that the studies in our meta-analysis had a high prevalence of malignancy, which raises the possibility that PET imaging may not be as accurate in populations with a lower prevalence of malignancy. As she notes, this is a concern only if the higher prevalence of disease in the studies is correlated with a more severe spectrum of disease. Studies will overestimate sensitivity if the disease is more severe in the study population than in the clinically relevant population.1 To assess whether this problem existed in the literature on PET imaging, we compared studies with a very high prevalence (mean, 80%) with those with a lower prevalence (mean, 64%) and found that PET imaging was more accurate in studies with a lower prevalence of malignancy (log odds ratio [OR], 5.19; 95% confidence interval [CI], 4.50-5.88) than those with the higher prevalence (log OR, 3.91; 95% CI, 3.34-4.58; P<.001 for difference). Thus, the available data do not support a correlation between prevalence and disease spectrum. Nevertheless, we agree that it is important to study a population with a full spectrum of disease severity.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.