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Letters |

Vitamin E Supplementation in Healthy Persons—Reply

Garret A. FitzGerald, MD; Emma Meagher, MD
JAMA. 2001;285(19):2449-2450. doi:10.1001/jama.285.19.2449.
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In Reply: In response to Dr Dixon, we designed the study in 8-week dosing intervals because these were sufficient to attain steady-state suppression of elevated urinary isoprostanes in patients with syndromes of oxidant stress and in animal models of disease.1,2 Steady-state circulating levels of vitamin E are attained much earlier than these pharmacodynamic responses. Clearly an impact on a chronic disease process in which lipid peroxidation may play a role, such as human atherosclerosis, may require longer periods of follow-up to assess clinical end points, even using contemporary approaches to measurement of plaque progression, such as electron beam computed tomography or magnetic resonance imaging.

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