To the Editor: It has been reported that 80% of patients with primary biliary cirrhosis (PBC) experience generalized fatigue.1,2 Although fatigue can significantly affect quality of life, few studies have addressed its etiology in PBC. Some reports suggest that there may be a significant organic component to the fatigue described by patients with PBC,2 perhaps as a result of peripheral muscle dysfunction.3 We sought to examine the relationship between peripheral muscle dysfunction and fatigue in a larger sample of patients with PBC.
A significant correlation between fatigue impact score and rate of decrease in muscle grip strength among PBC patients (r
= 0.69, P<.001).
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