To the Editor: Estrogen status appears to modify the risk of developing Alzheimer disease (AD).1 It has recently been proposed that this may be due to the effect of gonadal hormones on amyloid-β peptide (Aβ), which is the main neurotoxic component of cerebral amyloid found in AD.2- 4 Furthermore, rising plasma Aβ levels have been found to be associated with incipient AD,5 and a genetically linked phenotype of elevated plasma Aβ levels appears to be related to the risk for late-onset AD.6 We studied the effect of gonadal hormone withdrawal in men on plasma levels of Aβ1-40.
Plasma concentrations were determined serially on samples drawn 1 week prior to initiating treatment with flutamide and leuprorelin acetate and on weeks 4, 12, and 24.
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