To the Editor: Because buprenorphine has only partial opioid agonist activity and thus has a lower risk of overdose,1 it may be an alternative to methadone in the treatment of heroin dependence. Buprenorphine has been used for this purpose in France, where general practitioners have been permitted to prescribe it since 1996 with less monitoring than methadone, which is available only in specialized treatment centers.2 Buprenorphine thus has theoretically more risk of adverse effects and increased diversion than methadone. We computed the death rate from overdose of buprenorphine and methadone in France from 1994 to 1998.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 87
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.