In Reply: Dr Furuta and colleagues raise an
interesting and important point in asking for a detailed description of the
spectrum of phenotypes of the affected subjects in our genetic linkage study
of severe pediatric GER. Clearly, the symptoms of patients with primary nonsyndromic
pediatric GER, EE, and hiatal hernia can appear to be similar. It is thus
desirable when performing genetic linkage studies to ensure that all of the
affected individuals have the same phenotype.
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