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Letters |

Safety of Celecoxib vs Other Nonsteroidal Anti-inflammatory Drugs—Reply

James B. Lefkowith, MD; G. Steven Geis, MD, PhD; Fred Silverstein, MD
JAMA. 2000;284(24):3123-3124. doi:10.1001/jama.284.24.3123.
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In Reply: While we agree with Dr Köhler and colleagues that the CLASS trial supports the hypothesis that COX-2–specific inhibitors will produce fewer ulcers and ulcer complications than conventional NSAIDs, we disagree that the data suggest the possibility that celecoxib interferes with healing of aspirin-induced GI mucosal lesions. A prior study1 has found that the relative risk of an ulcer complication in aspirin users vs nonaspirin users is approximately the same as the relative risk of an ulcer complication in aspirin users receiving celecoxib vs nonaspirin users receiving celecoxib that we reported.

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